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原着论文
69. M. Munekane, K. Matsunaga, M. Ozaki, H. Echigo, K. Mishiro, T. Fuchigami, K. Ogawa*
“Auger Electron Therapy Enhanced by Heat-Triggered Release of I-125-Labeled DNA-Targeted
Compounds within the Tumor Microenvironment”
Mol. Pharm. 23 (9), 4681-4689 (2026)
68. H. Echigo, M. Munekane, T. Fuchigami, K. Mishiro, H. Kikunaga, K. Tsukada, T. Yokokita, K. Shirasaki, J. Ichinose, E. Hinoi,
S. Kinuya, K. Ogawa*
“Macropa-Based 225Ac-Labeled RGD Peptides for Targeted Alpha Therapy”
Mol. Pharm. 23 (9), 4611-4621 (2026)
67. N. Takemura, N. Fujii, K. Imai, K. Hyakunari, H. Takikawa, K. Mishiro*
“Hydrazonoyl Chlorides as Reagents for Preparative Carboxy-Group Modification of Peptides
in Aqueous Media”
Org. Lett. 28 (32), 10376-10381 (2026)
66. N. I. B. Ramzi, K. Tamamura, M. Munekane, K. Mishiro, T. Fuchigami, X. Hu, R. Jastrz?b, S. Kinuya, K. Ninomiya, K. Ogawa*
“Preparation and Evaluation of Radiolabeled Porphyrin-Functionalized Lipid Nanodroplets for Cancer Theranostics”
Molecules 31 (7), 1114 (2026)
65. K. Ogawa*, Y. Akita, K. Mishiro, M. Munekane, K. Tamamura, T. Fuchigami, M. Suzuki
“Development of theranostic agents combined with nuclear medicine imaging and boron neutron capture therapy (BNCT) for bone
metastases of cancer”
Nucl. Med. Biol. 150-151, 109518 (2025)
64. S. Deyama*, K. Mishiro, M. Kunishima, K. Kaneda
“L-type voltage-dependent calcium channels in the ventromedial orbitofrontal and prefrontal cortices mediate the inhibitory effects
of (S)-ketamine but not (R)-ketamine on marble burying in male mice”
Eur. J. Pharmacol. 1007, 178301 (2025)
63. N. Effendi*, M. Munekane, A. Malik, A. R. Putra, B. B. Patrianesha, R. Ritawidya, X. Hu, T. Fuchigami, K. Mishiro,
H. Wakabayashi, R. Jastrz?b, S. Kinuya, K. Ogawa*.
“Comparison of technetium-99m-labeled pentapeptides as bone imaging agents: influence of different types of acidic amino acids”
Chem. Pharm. Bull. 73(10), 1010-1016 (2025)
62. H. Echigo, M. Munekane, T. Fuchigami, K. Mishiro, K. Washiyama, E. Hinoi, K. Takahashi, H. Wakabayashi, S. Kinuya, K. Ogawa*
“Evaluation of an 211At-labeled RGD peptide in an orthotopic glioblastoma model by targeted alpha therapy”
Nucl. Med. Biol. 150-151, 109572 (2025)
61. K. Tamamura, Y. Akita, K. Mishiro, M. Munekane, T. Fuchigami, Y. Fujikawa, H. Wakabayashi, F. Ikoma, X. Hu, S. Kawabata,
S. Kinuya, M. Suzuki, K. Ogawa*
“Development of a theranostic agent for bone metastases: integration of nuclear medicine imaging and boron neutron capture therapy
(BNCT)”
Mol. Pharm. 22(9), 5546-5554 (2025)
60. H. Echigo, M. Munekane, T. Fuchigami, K. Washiyama, T. Nakamura, A. Furukawa, Z. Chen, K. Mishiro, H. Wakabayashi,
K. Takahashi, S. Kinuya, K. Ogawa*
“Combination therapy of an 211At-labeled RGD peptide and immune checkpoint blockade to enhance antitumor efficacy”
Eur. J. Nucl. Med. Mol. Imaging (2025) https://doi.org/10.1007/s00259-025-07498-3
59. S. Hirata, H. Echigo, M. Munekane, K. Mishiro, K. Washiyama, T. Fuchigami, H. Wakabayashi, K. Takahashi, S. Kinuya, K. Ogawa*
“Engineering a radiohybrid PSMA ligand with an albumin-binding moiety and pharmacokinetic modulation via an albumin-binding
competitor for radiotheranostics”
Molecules 30(13):2804 (2025)
58. T. Fuchigami*, K. Shimo, T. Hiwatashi, Y. Andoh, M. Munekane, K. Mishiro, H. Echigo, H. Wakabayashi, Y. Kitamura, S. Kinuya,
K. Ogawa
“Development of a radiogallium-labeled heterodivalent imaging probe targeting negative charges and integrin on the surface of cancer
cell membranes”
Mol. Pharm. 22(4), 2053-2064 (2025)
57. K. Hyakunari, K. Imai, K. Mishiro*
“Selective modification of carboxylic acids with oximoyl chlorides under aqueous conditions”
Org. Lett. 27 (26), 7206-7211 (2025)
56. K. Ogawa, R. Kobayashi, N. Okada, K. Mishiro*
“Light-induced conjugation of inorganic phosphate and sulfate with aminocyclobutenediones under aqueous conditions”
Chem. Eur. J. 31 (23), e202500187 (2025)
55. S. Hirata, K. Mishiro*, K. Washiyama, M. Munekane, T. Fuchigami, Y. Arano, K. Takahashi, S. Kinuya, K. Ogawa*
“In vivo stability improvement of astatobenzene derivatives by introducing neighboring substituents”
J. Med. Chem. 68 (2), 1540-1542 (2025)
54. H. Echigo, M. Munekane, T. Fuchigami, K. Washiyama, K. Mishiro, H. Wakabayashi, K. Takahashi, S. Kinuya, K. Ogawa*
“Optimizing the pharmacokinetics of an 211At-labeled RGD peptide with an albumin-binding moiety via the administration of
an albumin-binding inhibitor”
Eur. J. Nucl. Med. Mol. Imaging 51 (9), 2663-2671 (2024)
53. H. Echigo, K. Mishiro, M. Munekane, T. Fuchigami, K. Washiyama, K. Takahashi, Y. Kitamura, H. Wakabayashi, S. Kinuya,
K. Ogawa*
“Development of probes for radiotheranostics with albumin binding moiety to increase the therapeutic effects of astatine-211 (211At)”
Eur. J. Nucl. Med. Mol. Imaging 51 (2), 412-421 (2024)
52. M. Fawwaz*, K. Mishiro*, A. Arwansyah, R. Nishii, K. Ogawa*
“Synthesis and initial in vitro evaluation of olmutinib derivatives as prospective imaging probe for non-small cell lung cancer”
Bioimpacts 14 (1), 27774 (2024)
51. M. Fawwaz*, K. Mishiro*, B. Purwono*, R. Nishii, K. Ogawa
“Synthesis and evaluation of a rociletinib analog as prospective imaging double mutation L858R/T790M in non-small cell lung cancer”
J. Pharm. Pharm. Res. 12 (2), 231-242 (2024)
50. S. Mogami, M. Baba, T. Furuyama, M. Kunishima*, K. Mishiro*
“Phototriggered generation of ynol ethers and their rearrangement to ketenes”
J. Org. Chem. 89 (15), 10709-10718 (2024)
49. K. Ogawa*, K. Nishizawa, K. Mishiro, M. Munekane, T. Fuchigami, H. Echigo, H. Wakabayashi, S. Kinuya
“Differences in the renal accumulation of radiogallium-labeled (Glu)14 peptides containing different optical isomers of glutamic acid”
Molecules 29 (17), 3993 (2024)
48. M. Munekane*, M. Ozaki, Y. Mitani, N. Sakaida, K. Sano, T. Yamasaki, T. Mukai, K. Mishiro, T. Fuchigami, K. Ogawa*
“Development of radiolabeled probes with improved imaging contrast by releasing urinary excretable radiolabeled compounds
from thermosensitive liposomes in the blood”
Mol. Pharm. 21 (11), 5728-5735 (2024)
47. K. Ogawa*, K. Nishizawa, K. Mishiro, N. Effendi, T. Fuchigami, M. Munekane, H. Wakabayashi, S. Kinuya
“Synthesis and evaluation of radiogallium labeled bone-imaging probes using oligo-γ-carboxy glutamic acid peptides as carriers to bone”
Mol. Pharm. 21 (5), 2375-2382 (2024)
46. K. Mishiro*, A. Sesumi, T. Fujii, T. Furuyama, M. Kunishima*
“Phototriggered butenolide formation from a cyclobutenedione and an acidic nucleophile”
Org. Lett. 26 (1), 380-384 (2024)
45. M. E. N. Elghobary, M. Munekane*, K. Mishiro, T. Fuchigami, K. Ogawa*
“Preparation and evaluation of thermosensitive liposomes encapsulating I-125-labeled doxorubicin derivatives for auger electron therapy”
Molecules 28 (4), 1864 (2023)
44. S. Horie, K. Mishiro, M. Nishino, I. Domae, M. Wakasugi, T. Matsunaga, M. Kunishima*
“Epitope-based specific antibody modifications”
Bioconjug. Chem. 34 (11), 2022-2033 (2023)
43. H. Ichida, T. Fukami*, K. Amai, K. Suzuki, K. Mishiro, S. Takano, W. Obuchi, Z. Zhang, A. Watanabe, M. Nakano, K. Watanabe,
M. Nakajima
“Quantitative evaluation of the contribution of each aldo-keto reductase and short-chain dehydrogenase/reductase isoform to reduction
reactions of compounds containing a ketone group in the human liver”
Drug Metab. Dispos. 51 (1), 17-28 (2023)
42. H. Ichida, T. Fukami*, T. Kudo, K. Mishiro, S. Takano, M. Nakano, G. Morinaga, A. Matsui, N. Ishiguro, M. Nakajima
“Identification of HSD17B12 as an enzyme catalyzing drug reduction reactions through investigation of nabumetone metabolism”
Arch. Biochem. Biophys. 736, 109536 (2023)
41. K. Mishiro*, T. Ueno, H. Wakabayashi, M. Fukui, S. Kinuya, K. Ogawa*
“Synthesis and evaluation of a deltic guanidinium analogue of a cyclic RGD peptide”
Org. Biomol. Chem. 21 (9), 1937-1941 (2023)
40. K. Ogawa*, K. Nishizawa, K. Washiyama, M. Munekane, T. Fuchigami, H. Echigo, K. Mishiro, S. Hirata, H. Wakabayashi,
K. Takahashi, S. Kinuya
“Astatine-211-labeled aza-vesamicol derivatives as sigma receptor ligands for targeted alpha therapy”
Nucl. Med. Biol. 122-123, 108369 (2023)
39. H. Echigo, K. Mishiro, M. Munekane, T. Fuchigami, Y. Kitamura, S. Kinuya, K. Ogawa*
“Development and evaluation of a theranostic probe with RGD peptide introduced platinum complex to enable tumor-specific
accumulation”
Bioorg. Med. Chem. 70, 116919 (2022)
38. S. Hirata, K. Mishiro, T. Higashi, T. Fuchigami, M. Munekane, Y. Arano, S. Kinuya, K. Ogawa*
“Synthesis and evaluation of a multifunctional probe with a high affinity for prostate-specific membrane antigen (PSMA) and bone”
Nucl. Med. Biol. 114-115, 34-41 (2022)
37. K. Mishiro, S. Imai, Y. Ematsu, K. Hirose, T. Fuchigami, M. Munekane, S. Kinuya, K. Ogawa*
“RGD peptide-conjugated dodecaborate with the Ga-DOTA complex: a preliminary study for the development of theranostic agents for
boron neutron capture therapy and its companion diagnostics”
J. Med. Chem. 65 (24), 16741-16753 (2022)
36. I. Nozaki, N. Ishikawa, Y. Miyanari, K. Ogawa, A. Tagawa, S. Yoshida, M. Munekane, K. Mishiro, A. Toriba, M. Nakayama,
T. Fuchigami*
“Borealin-derived peptides as survivin-targeting cancer imaging and therapeutic agents”
Bioconjug. Chem. 33 (11), 2149-2160 (2022)
35. N. I. Ramzi, K. Mishiro, M. Munekane, T. Fuchigami, X. Hu, R. Jastrz?b, Y. Kitamura, S. Kinuya, K. Ogawa*
“Synthesis and evaluation of radiolabeled porphyrin derivatives for cancer diagnoses and their nonradioactive counterparts for
photodynamic therapy”
RSC Med. Chem. 13 (12), 1565-1574 (2022)
34. K. Mishiro, M. Wang, S. Hirata, T. Fuchigami, K. Shiba, S. Kinuya, K. Ogawa*
“Development of tumor-targeting aza-vesamicol derivatives with high affinity for sigma receptors for cancer theranostics”
RSC Med. Chem. 13 (8), 986-997 (2022)
33. H. Kondo, K. Mishiro, Y. Iwashima, Y. Qiu, A. Kobayashi, K. Lim, T. Domoto, T. Minamoto, K. Ogawa, M. Kunishima,
M. Hazawa*, R. W. Wong*
“Discovery of a novel aminocyclopropenone compound that inhibits BRD4-driven nucleoporin NUP210 expression and attenuates
colorectal cancer growth”
Cells 11 (3), 317 (2022)
32. K. Mishiro, R. Nishii, I. Sawazaki, T. Sofuku, T. Fuchigami, H. Sudo, N. Effendi, A. Makino, Y. Kiyono, K. Shiba, J. Taki,
S. Kinuya, K. Ogawa*
“Development of radiohalogenated osimertinib derivatives as imaging probes for companion diagnostics of osimertinib”
J. Med. Chem. 65 (3), 1835-1847 (2022)
31. H. Hashizume, T. Fukami*, K. Mishima, H. Arakawa, K. Mishiro, Y. Zhang, M. Nakano, M. Nakajima
“Identification of an isoform catalyzing the CoA conjugation of nonsteroidal anti-inflammatory drugs and the evaluation of the
expression levels of acyl-CoA synthetases in the human liver”
Biochem. Pharmacol. 183, 114303 (2021)
30. N. Effendi, K. Mishiro, H. Wakabayashi, M. Gabryel-Skrodzka, K. Shiba, J. Taki, R. Jastrz?b, S. Kinuya, K. Ogawa*
“Synthesis and evaluation of radiogallium-labeled long-chain fatty acid derivatives as myocardial metabolic imaging agents”
PLoS One. 16, e0261226 (2021)
29. H. Echigo, K. Mishiro, T. Fuchigami, K. Shiba, S. Kinuya, K. Ogawa*
“Synthesis and evaluation of a dimeric RGD peptide as a preliminary study for radiotheranostics with radiohalogens”
Molecules 26 (20), 6107 (2021)
28. K. Ogawa*, H. Echigo, K. Mishiro, S. Hirata, K. Washiyama, Y. Kitamura, K. Takahashi, K. Shiba, S. Kinuya
“68Ga- and 211At-labeled RGD peptides for radiotheranostics with multiradionuclides”
Mol. Pharm. 18 (9), 3553-3562 (2021)
27. M. Fawwaz, K. Mishiro, R. Nishii, A. Makino, Y. Kiyono, K. Shiba, S. Kinuya, K. Ogawa*
“A radiobrominated tyrosine kinase inhibitor for EGFR with L858R/T790M mutations in lung carcinoma”
Pharmaceuticals 14 (3), 256 (2021)
26. K. Mishiro*, M. Nomura, T. Furuyama, M. Kunishima*
“Efficiency enhancement of a photocatalytic decarbonylation of an aminocyclopropenone by benzothiophene substitution”
J. Org. Chem. 86 (4), 3625-3636 (2021)
25. N. Effendi, K. Mishiro, K. Shiba, S. Kinuya, K. Ogawa*
“Development of radiogallium-labeled peptides for platelet-derived growth factor receptor β (PDGFRβ) imaging: influence of
different linkers”
Molecules 26 (1), 41 (2021)
24. Y. Masuo, K. I. Fujita, K. Mishiro, N. Seba, T. Kogi, H. Okumura, N. Matsumoto, M. Kunishima, Y. Kato*
“6-Hydroxyindole is an endogenous long-lasting OATP1B1 inhibitor elevated in renal failure patients”
Drug Metab. Pharmacokinet. 35 (6), 555-562 (2020)
23. K. Ogawa*, T. Higashi, K. Mishiro, H. Wakabayashi, K. Shiba, A. Odani, S. Kinuya
“Decreasing undesirable absorbed radiation to the intestine after administration of radium-223 dichloride for treatment of bone metastases”
Sci. Rep. 10 (1), 11917 (2020)
22. M. Fawwaz, K. Mishiro, R. Nishii, I. Sawazaki, K. Shiba, S. Kinuya, K. Ogawa*
“Synthesis and fundamental evaluation of radioiodinated rociletinib (CO-1686) as a probe to lung cancer with L858R/T790M mutations
of epidermal growth factor receptor”
Molecules 25, 12, (2020)
21. M. Yanagi, Y. Ueda*, R. Ninomiya, A. Imayoshi, T. Furuta, K. Mishiro, T. Kawabata*
“Synthesis of 4-deoxy pyranosides via catalyst-controlled aite-aelective toluoylation of abundant sugars”
Org. Lett. 21 (13), 5006-5009 (2019)
20. K. Mishiro*, T. Kimura, T. Furuyama, M. Kunishima*
“Phototriggered active alkyne generation from cyclopropenones with visible light-responsive photocatalysts”
Org. Lett. 21 (11), 4101-4105 (2019)
19. K. Ogawa*, T. Takeda, K. Mishiro, A. Toyoshima, K. Shiba, T. Yoshimura, A. Shinohara, S. Kinuya, A. Odani
“Radiotheranostics coupled between an At-211-labeled RGD peptide and the corresponding radioiodine-labeled RGD peptide”
ACS Omega 4 (3), 4584-4591 (2019)
18. K. Ogawa*, R. Masuda, K. Mishiro, M. Wang, T. Kozaka, K. Shiba, S. Kinuya, A. Odani
“Syntheses and evaluation of a homologous series of aza-vesamicol as improved radioiodine-labeled probes for sigma-1 receptor imaging”
Bioorg. Med. Chem. 27 (10), 1990-1996 (2019)
17. A. Ishizaki, K. Mishiro, K. Shiba, H. Hanaoka, S. Kinuya, A. Odani, K. Ogawa*
“Fundamental study of radiogallium-labeled aspartic acid peptides introducing octreotate derivatives”
Annal. Nucl. Med. 33 (4), 244-251 (2019)
16. N. Effendi, K. Mishiro, T. Takarada, D. Yamada, R. Nishii, K. Shiba, S. Kinuya, A. Odani, K. Ogawa*
“Design, synthesis, and biological evaluation of radioiodinated benzo[d]imidazole-quinoline derivatives for platelet-derived growth factor
receptor β (PDGFRβ) imaging”
Bioorg. Med. Chem. 27 (2), 383-393 (2019)
15. T. Ogiso, T. Fukami*, K. Mishiro, K. Konishi, J. P. Jones, M. Nakajima
“Substrate selectivity of human aldehyde oxidase 1 in reduction of nitroaromatic drugs”
Arch. Biochem. Biophys. 659, 85-92 (2018)
14. K. Mishiro*, Y. Yushima, M. Kunishima*
“Phototriggered ketone formation from an aminocyclopropenone and a carboxylic acid”
J. Org. Chem. 83 (21), 13595-13603 (2018)
13. N. Effendi, K. Mishiro, T. Takarada, A. Makino, D. Yamada, Y. Kitamura, K. Shiba, Y. Kiyono, A. Odani, K. Ogawa*
“Radiobrominated benzimidazole-quinoline derivatives as platelet-derived growth factor receptor beta (PDGFRβ) imaging probes”
Sci. Rep. 8 (1), 10369 (2018)
12. K. Mishiro*, Y. Yushima, M. Kunishima*
“Phototriggered dehydration condensation using an aminocyclopropenone”
Org. Lett. 19 (18), 4912-4915 (2017)
11. N. Effendi, K. Ogawa*, K. Mishiro, T. Takarada, D. Yamada, Y. Kitamura, K. Shiba, T. Maeda, A. Odani
“Synthesis and evaluation of radioiodinated 1-{2-[5-(2-methoxyethoxy)-1H-benzo [d] imidazol-1-yl] quinolin-8-yl} piperidin-4-amine
derivatives for platelet-derived growth factor receptor β (PDGFRβ) imaging”
Bioorg. Med. Chem. 25 (20), 5576-5585 (2017)
10. K. Mishiro, F. Hu, D. W. Paley, W. Min, T. H. Lambert*
“Macrosteres: the deltic guanidinium ion”
Eur. J. Org. Chem., (9), 1655-1659 (2016)
9. K. Mishiro, H. Takeuchi, T. Furuta, T. Kawabata*
“A concise access to C2-symmetric chiral 4-pyrrolidinopyridine catalysts with dual functional side chains”
Chem. Pharm. Bull., 64 (7), 1073-1077 (2016)
8. H. Takeuchi, K. Mishiro, Y. Ueda, Y. Fujimori, T. Furuta, T. Kawabata*
“Total synthesis of ellagitannins via regioselective sequential functionalization of unprotected glucose”
Angew. Chem. Int. Ed. 54 (21), 6177-6180 (2015)
7. J. Beswick, V. Blanco, G. De Bo, D. A. Leigh,* U. Lewandowska, B. Lewandowski, K. Mishiro
“Selecting reactions and reactants using a switchable rotaxane organocatalyst with two different active sites”
Chem. Sci.，6 (1), 140-143 (2015)
6. K. Mishiro*, T. Furuta, T*. Sasamori, K. Hayashi, N. Tokitoh, S. Futaki, T. Kawabata
“A cyclochiral conformational motif constructed using a robust hydrogen-bonding network”
J. Am. Chem. Soc. 135 (37), 13644-13647 (2013)
5. H. Schedel, K. Kan, Y. Ueda, K. Mishiro, K. Yoshida, T. Furuta, T. Kawabata*
“Asymmetric desymmetrization of meso diols by C2-symmetric chiral 4-pyrrolidinopyridines”
Beilstein J. Org. Chem. 8, 1778-1787 (2012)
4. K. Yoshida, K. Mishiro, Y. Ueda, T. Shigeta, T. Furuta, T. Kawabata*
“Nonenzymatic geometry-selective acylation of tri- and tetrasubstituted α,α'-alkenediols”
Adv. Synth. Catal. 354 (17), 3291-3298 (2012)
3. Y. Ueda, K. Mishiro, K. Yoshida, T. Furuta, T. Kawabata*
“Regioselective diversification of a cardiac glycoside, lanatoside C, by organocatalysis”
J. Org. Chem. 77 (18), 7850-7857 (2012)
2. W. Muramatsu, K. Mishiro, Y. Ueda, T. Furuta, T. Kawabata*
“Perfectly regioselective and sequential protection of glucopyranosides”
Eur. J. Org. Chem. (5), 827-831 (2010)
1. Y. Ueda, W. Muramatsu, K. Mishiro, T. Furuta, T. Kawabata*
“Functional group tolerance in organocatalytic regioselective acylation of carbohydrates”
J. Org. Chem. 74 (22), 8802-8805 (2009)
