2026年度

  1. Ando, H., Yamaguchi, S., Shimazaki, Y., Kuramoto, R., Sunami, T., Takata, H., Ishida, T., Spleen-targeting immunization with antigen-loaded PEGylated liposomes enhances the diversity of antigen-specific antibodies. Next Research, 4, 101229 (2026)
  2. Fukuda, S., Takata, H., Hayashi, R., Yamamoto, H., Nakae, T., Tatsumi, N., Hamamoto, H., Kobayashi, S., Ando, H., Ishida T., Ionic liquids composed of Lactic acid and Trometamol enhance the oral absorption of 10 kDa dextran, as a model compound of mid-sized molecules. Biol. Pharm. Bull., 49, 141-148 (2026)
  3. Baatartsogt, N., Kashiwakura, Y., Hiramoto, T., Ito, R., Sato, R., Nagao, Y., Naruoka, H., Takata, H., Hayakawa, M., Batjargal, K., Togashi, T., Hoshino, A., Shimizu, T., Sato, Y., Ishida, T., Nureki, O., Ohmori, T., Therapeutic base editing to generate a gain-of-function F9 variant for hemophilia B. Blood, 147, 458-470 (2026)

研究费获得状况

  1. 横山临床薬理研究助成基金「研究助成金」（新规）
  2. 科学研究费补助金「挑戦的研究（萌芽）」（継続）
  3. 科学研究费补助金「基盘颁」（継続）
  4. 小林财団「研究助成」（継続）
  5. 科学研究费补助金「基盘叠」（継続）
  6. キヤノン财団「研究助成金」（継続）
  7. 科学研究费补助金「挑戦的研究（开拓）」（継続）

2025年度

  1. Ikeda-Imafuku, M., Sakai, M., Umezawa, K., Nakagawa, H., Maruyama, T., Otagiri, M., Akaike, T., Sawa, T., Xian, M., Miura, Y., Ishida, T., Ishima, Y., Unique response of polysulfide in serum albumin to oxidative stress. Sci. Rep., 15, 42689 (2025)
  2. Mogi, K., Morimoto, H., Yasukawa, T., Uozumi, Y., Ishida, T., Nagasawa, K., Effect of PEGylated liposomalization of oxaliplatin on the gut microbiota in mice. Biol. Pharm. Bull., 48, 1932–1939 (2025)
  3. Kawaguchi, Y., Kimura, M., Karaki, T., Tanaka, H., Ono, C., Ishida, T., Matsuura, Yo., Hirai, T., Akita, H., Shimizu, T., Yoshioka, Y., Modulating immunogenicity and reactogenicity in mRNA-lipid nanoparticle vaccines through lipid component optimization. ACS Nano, 19, 27977-28001 (2025)
  4. Matsuo, N., Ando, H., Takata, H., Ishida, T., Protein-bound cisplatin could exhibit an efficient antitumor effect in vivo. J. Pharm. Sci., 114, 103881 (2025)
  5. Chan, V., Lee, H., Takata, H., Cheng, S., Yen, Y., Pfeifer, L., Rushton, L., Chao, P., Zhao, F., Ong, C., Al-Fayez, N., Ishida, T., Chen, Y., Li, S., Imiquimod-loaded phospholipid-free small unilamellar vesicles activate the tumour immune microenvironment to treat liver cancer and liver metastases. Adv. Healthcare Mater., 14, 2501691 (2025)
  6. Abe, S., Takata, H., Shimizu, T., Kawaguchi, Y., Fukuda, S., Yamamoto, H., Ando, H., Ishida, T., Impact of pre-existing anti-polyethylene glycol (PEG) IgM on biodistribution and humoral response of intramuscularly administered PEGylated mRNA loaded lipid nanoparticle. J. Control. Release, 383, 113821 (2025)
  7. Nii, T., Yoshimi, T., Tanito, K., Hijii, S., Takata, H., Kishimura, A., Mori, T., Ishida, T., Katayama, Y., Inflammation-triggering engineered macrophages (MacTriggers) are promising cell-based therapeutic avenues for chemoresistant solid tumors. Anticencer Res., 45, 1395-1405 (2025)
  8. Liu, Y., Mor, T., Ito, Y, Kuroki, K., Hayashi, S., Kohda, D., Shimizu, T., Ishida, T., Roffler, S.R., Kaneko, M.K., Kato, Y., Arimori, T., Teramoto, T., Takemura, K., Ishibashi, K., Katayama, Y., Maenaka, K., Kakuta, Y., Kitao, A., Mori, T., The strategy used by naïve anti-PEG antibodies to capture flexible and featureless PEG chains. J. Control. Release, 380, 396-403 (2025)
  9. Shimizu, T., Abe, S., Kawaguchi, Y., Takata, H., Ando, H., Ishida, T., A spleen-targeted vaccine for SARS-CoV-2 — inducting neutralizing antibodies in mice. J. Pharm. Sci., 114, 1615-1624 (2025)
  10. Kawaguchi, Y., Shimizu, T., Takata, H., Ando, H., Ishida, T., An in vitro nanocarrier-based B cell antigen loading system; tumor growth suppression via transfusion of the antigen-loaded B cells in vivo. Int. J. Pharm., 670, 125189 (2025)
  11. Akagi, S., Ando, H., Matsuo, N., Tajima, K., Takata, H., Matsushima, T., Kusano, T., Ishida, T., A 3D cell-culture system that uses nano-fibrillated bacterial cellulose (NFBC) to prepare a spherical formulation of culture cells. Biol. Pharm. Bull., 48, 23-32 (2025)
  12. 安藤英紀、松尾アモリムクリスティーナ菜々、高田春風、石田竜弘、マウスからの採血方法、Drug Delivery System, 40-2, 156-158 (2025)
  13. 小暮健太朗、石田竜弘、徳岛大学大学院医歯薬学研究部DDS研究センターの紹介、Pharm. Tech. Japan, 41, 81-86 (2025)
  14. 高田春風、医薬品をより安全に、より有効に～PEG修飾ナノ粒子製剤の安全使用のために～、薬剤学、85、236-240 (2025)
  15. 高田春風、石田竜弘、ポストコロナ時代における抗PEG 抗体、ファルマシア：最前線, 61, 221-226 (2025)
  16. 上野良之、辻理一郎、西本豊、本白水崇光、石田竜弘、上田一樹、清水太郎、松村保広、森本展行、横山昌幸、白石貢一、太田琴恵、座談会：DDS材料における現状と今後、Drug Delivery System, 40-3, 172-178 (2025)

研究费获得状况

  1. 加藤记念バイオサイエンス振兴财団「国际交流助成」（新规）
  2. 科学研究费补助金「挑戦的研究（萌芽）」（新规）
  3. 科学研究费补助金「基盘颁」（新规）
  4. 日本科学协会「笹川科学研究助成金」（新规）
  5. 小林财団「研究助成」（新规）
  6. 科学研究费补助金「基盘叠」（継続）
  7. 科学研究费补助金「特别研究员奨励费」（継続）
  8. キヤノン财団「研究助成金」（継続）
  9. 日本医疗研究开発机构（础惭贰顿）「创薬基盘推进研究事业」（継続）
  10. 科学研究费补助金「挑戦的研究（开拓）」（継続）
  11. 科学研究费补助金「基盘叠」（継続）

2024年度

  1. Kaneko, E., Tsujisaki, H., Fujiwara, M., Ando, H., Sato, Y., Ishida, T., Tani, H., Tajima, K., Application of bacterial-derived long cellulose nanofiber to suspension culture of mammalian cells as a shear protectant. Int. J. Biol. Macromol., 280, 135938 (2024)
  2. Najmina, M., Kobayashi, S., Shimazui, R., Takata, H., Shibata, M., Ishibashi, K., Kamizawa, H., Kishimura, A., Shiota, Y., Ida, D., Shimizu, T., Ishida, T., Katayama, Y., Tanaka, M., Mori, T., A stealthiness evaluation of main chain carboxybetaine polymer modified into liposome. Pharmaceutics, 16, 1271 (2024)
  3. Hori, T., Shimizu, T., Ando, H., Okada, N., Yamagami, H., Yasui, S., Hosoki, M., Tojima, A., Otoda, T., Yuasa, T., Aihara, K., Takishita, M., Yoshida, S., Abe, M., Ishida, T., Nakamura, S., Humoral immune response against SARS-CoV-2 and polyethylene glycol elicited by anti-SARS-CoV-2 mRNA vaccine, and effect of pre-existing anti-polyethylene glycol antibody in patients with hematological and autoimmune diseases. Heliyon, 10, e31489 (2024)
  4. Shimizu, T., Abu Lila, A., Kitayama, Y., Abe, R., Takata, H., Ando, H., Ishima, Y., Ishida, T., Peritoneal B Cells Play a Role in The Production of Anti-Polyethylene Glycol (PEG) IgM Against Intravenously Injected siRNA-PEGylated Liposome Complexes. Biol. Pharm. Bull., 47, 469-477 (2024)
  5. Ikeda-Imafuku, M., Fukuta, T., Chuang, V., Sawa, T., Maruyama, T., Otagiri, M., Ishida, T., Ishima, Y., Acute kidney injury caused by rhabdomyolysis is ameliorated by serum albumin-based supersulfides donors through antioxidative pathways. Pharmaceuticals, 17, 128 (2024)
  6. Gaballa, S., Shimizu, T., Takata, H., Ando, H., Ibrahim, M., Emam, S., Matsuo, N., Kim, Y., Naguib, Y., Mady, F., Khaled, K., Ishida, T., Impact of anti-PEG IgM induced via the topical application of a cosmetic product containing PEG derivatives on the antitumor effects of PEGylated liposomal antitumor drug formulations in mice, Mol. Pharmaceutics, 21, 622-632 (2024)
  7. Hirai, T., Ikeda-Imafuku, M., Tasaka, N., Tuan Giam Chuang, V., Xian, M., Ishida, T., Akaike, T., Ishima, Y., Human hair keratin responds to oxidative stress via reactive sulfur and supersulfides, Adv. Redox Res., 10, 100091 (2024)
  8. Sakai, H., Kure, T., Kobayashi, N., Ito, T., Yamada, Y., Yamada, T., Miyamoto, R., Imaizumi, T., Ando, J., Soga, T., Osanai, Y., Ogawa, M., Shimizu, T., Ishida, T., Azuma, H., Absence of Anaphylactic Reactions to Injection of Hemoglobin-vesicles (Artificial Red Cells) to Rodents, ACS Omega, 9, 1904–1915 (2024)
  9. Gaballa, S., Shimizu, T., Ando, H., Takata, H., Emam, S., Ramadan, E., Naguib, Y., Mady, F., Khaled, K., Ishida, T., Treatment-induced and pre-existing anti-PEG antibodies: Prevalence, clinical implications, and future perspectives. J. Pharm. Sci., S0022-3549, 00472-0 (2024)
  10. 池田真由美、福田達也、岩尾康範、小田切優樹、丸山徹、石田竜弘、異島優、血清アルブミンに存在する超硫黄の解析と創薬応用、薬学雑誌、144, 51-56 (2024)

研究费获得状况

  1. 内藤记念科学振兴财団「科学奨励金?研究助成」（新规）
  2. 日本科学协会「海外発表促进助成」（新规）
  3. 加藤记念バイオサイエンス振兴财団「国际交流助成金」（新规）
  4. 日本科学协会「笹川科学研究助成金」（新规）
  5. 金原一郎医学医疗振兴财団「研究交流助成金」（新规）
  6. 科学研究费补助金「基盘叠」（新规）
  7. 科学研究费补助金「特别研究员奨励费」（新规）
  8. キヤノン财団「研究助成金」（新规）
  9. ヒロセ财団「研究助成金」（新规）
  10. 日本医疗研究开発机构（础惭贰顿）「创薬基盘推进研究事业」（継続）
  11. 科学研究费补助金「研究活动スタート支援」（継続）
  12. 科学研究费补助金「挑戦的研究（开拓）」（継続）
  13. 科学研究费补助金「基盘叠」（継続）
  14. 科学研究费补助金「特别研究员奨励费」（継続）
  15. 科学研究费补助金「国际共同研究强化叠」（継続）

2023年度

  1. Yasuda, K., Maeda, H., Kinoshita, R., Minayoshi, Y., Mizuta, Y., Nakamura, Y., Imoto, S., Nishi, K., Yamasaki, K., Sakuragi, M., Nakamura, T., Ikeda-Imafuku, M., Iwao, Y., Ishima, Y., Ishida, T., Iwakiri, Y., Otagiri, M., Watanabe, H., Maruyama, T., Encapsulation of an Antioxidant in Redox-Sensitive Self-Assembled Albumin Nanoparticle for the Treatment of Hepatitis. ACS Nano, 17, 16668-16681 (2023)
  2. Takata, H., Shimizu, T., Yamade, R., Elsadek, N.E., Emam, S.E., Ando, H., Ishima, Y., Ishida, T., Anti-PEG IgM production induced by PEGylated liposomes as a function of administration route. J. Control. Release, 360, 285–292 (2023)
  3. Ando, H., Eshima, K., Ishida, T., A polyethylene glycol-conjugate of deoxycytidine analog, DFP-14927, produces potential antitumor effects on pancreatic tumor-xenograft murine models via inducing G2/M arrest. Eur. J. Phamacol., 950, 175758 (2023)
  4. Shimizu, T. Matsuzaki, T., Fukuda, S., Yoshioka, C., Shimazaki, Y., Takese, S., Yamanaka, K., Nakae, T., Ishibashi, M., Hamamoto, H., Ando, H., Ishima, Y., Ishida, T., Ionic liquid-based transcutaneous peptide antitumor vaccine; therapeutic effect in a mouse tumor model. The AAPS J., 25:27 (2023)
  5. Ibrahim, M., Shimizu, T., Ando, H., Ishima, Y., Elgarhy, O.H., Sarhan, H.A., Hussein, A.K., Ishida, T., Investigation of anti-PEG antibody response to PEG-containing cosmetic products in mice. J. Control. Release, 354, 260-267 (2023)
  6. Okada, N., Shimizu, T., Ando, H., Nakamura, S., Goda, M., Abe, M., Kitahara, T., Ishida, T., Ishizawa, K., Clinical impact of anti-polyethylene glycol (PEG) antibody in haematological patients administered PEGylated-granulocyte colony-stimulating factor. Clin. Pharmacol. Drug Develop., 12, 826–831 (2023)
  7. Sawa-Aihara, A., Hattori, K., Nagao, G., Yamada, Y., Ishida, T., Potential efficacy of proteasome inhibitor, Delanzomib, for the treatment of renal fibrosis. Biol. Pharm. Bull., 46, 279-285 (2023)
  8. Emam S.E., Elsadek, N.E., Shimizu, T., Ishida, T., The Post-insertion Method for the Preparation of PEGylated Liposomes. in Liposomes Methods and Protocols (3rd Edition), a part of the book series: Methods in Molecular Biology (MiMB), D’Souza, G.G.M., Zhan, H. (Ed.), Springer, 159-172 (2023)
  9. 横山宏司、儘田光和、高田春風、清水太郎、安藤英紀、石田竜弘、マクロゴール4000の関連する全身性紅斑を呈した女児例、小児科、64, 1196-1199 (2023)
  10. 清水太郎、濱本英利、石田竜弘、イオン液体を利用した外用剤?経皮吸収製剤の開発と疾患治療への応用、Drug Delivery System, 38, 231-238 (2023)

研究费获得状况

  1. 科学研究费补助金「研究活动スタート支援」（新规）
  2. 科学研究费补助金「挑戦的研究（开拓）」（新规）
  3. 日本学术振兴会外国人特别研究员（闯厂笔厂サマー?プログラム）调査研究费（新规）
  4. 科学研究费补助金「基盘叠」（新规）
  5. 桥渡し研究戦略的推进プログラム?研究开発シーズ础（新规）
  6. 先进医薬研究振兴财団「研究助成金」（新规）
  7. テルモ生命科学振兴财団「研究助成金」（新规）
  8. 高桥产业経済研究财団「研究助成金」（継続）
  9. 日本医疗研究开発机构（础惭贰顿）「创薬基盘推进研究事业」（継続）
  10. 狈贰顿翱「官民による若手研究者発掘支援事业／共同研究フェーズ」（継続）
  11. 科学研究费补助金「基盘叠」（継続）
  12. 科学研究费补助金「特别研究员奨励费」（継続）
  13. 科学研究费补助金「国际共同研究强化叠」（継続）

2022年度

  1. Tachibana, K., Kusumoto, K., Ogawa, M., Ando, H., Shimizu, T., Ishima, Y., Ishida, T., Okuhira, K., FTY720 reduces lipid accumulation by upregulating ABCA1 through liver X receptor and sphingosine kinase 2 signaling in macrophages. Int. J. Mol. Sci., 23, 14617 (2022)
  2. Sumitomo, R., Huang, C., Ando, H., Ishida, T., Cho, H., Date, H., Wnt2b and Wnt5a expressions are highly associated with M2 TAMs in non-small-cell lung cancer. Oncol. Rep., 48, 189 (2022)
  3. Ando, H., Ikeda, A., Tagami, M., Matsuo, N., Shimizu, T., Ishima, Y., Eshima, K., Ishida, T., Oral administration of sodium bicarbonate can enhance the therapeutic outcome of Doxil® via neutralizing the acidic tumor microenvironment. J. Control. Release, 350, 414-420 (2022)
  4. Azuma, H., Amano, T., Kamiyama, N., Takehara, N., Jingu, M., Takagi, H., Sugita, O., Kobayashi, N., Kure, T., Shimizu, T., Ishida, T., Matsumoto, M., Sakai, H., First-in-human Phase 1 trial of artificial red blood cells, hemoglobin vesicles, developed as a transfusion alternative. Blood Advances, 6, 5711–5715 (2022)
  5. Ishima, Y., Yamazaki, N., Chuang, V., Shimizu, T., Ando, H., Ishida, T., A maleimide-terminally modified PEGylated liposome induced the accelerated blood clearance independent of the production of anti-PEG IgM antibodies. Biol. Pharm. Bull., 45, 1518-1524 (2022)
  6. Kawaguchi, Y., Shimizu, T., Ando, H., Ishima, Y., Ishida, T., Development of a nanocarrier-based splenic B cell-targeting system for loading antigens in vitro, Biol. Pharm. Bull., 45, 926-933 (2022)
  7. El Sayed, M., Shimizu, T., Abu Lila, A., Elsadek, N., Emam, S., Alaaeldin, E., Kamal, A., Sarhan, H., Ando, H., Ishima, Y., Ishida, T., A mouse model for studying the effect of blood anti-PEG IgMs levels on the in vivo fate of PEGylated liposomes. Int. J. Pharm., 615, 121539 (2022)
  8. Nakamura, K., Aihara, K., Ishida, T., Importance of process parameters influencing the mean diameters of siRNA-containing lipid nanoparticles (LNPs) on the in vitro activity of prepared LNPs. Biol. Pharm. Bull., 45, 497-507 (2022)
  9. Nakajima, T., Nagano, K., Fukuda, Y., Ishima, Y., Shibata, H., Isaka, R., Zhang, T., Haga, Y., Higashisaka, K., Tsujino, H., Ishida, T., Ishii-Watabe, A., Tsutsumi, Y., Subvisible particles derived by dropping stress enhance anti-PEG antibody production and clearance of PEGylated proteins in mice. J. Pharm. Sci. 111, 1363-1369 (2022)
  10. Ando-Matsuoka, R., Ando, H., Abu Lila, A.S., Maeda, N., Shimizu, T., Ishima, Y., Ishida, T., I.p.-injected cationic liposomes are retained and accumulate in peritoneally disseminated tumors. J. Control. Release, 341, 524-532 (2022)
  11. Mahmoud Mostafa, M., Elsadek, N.E., Emam, S.E., Ando, H., Shimizu, T., Abdelkader, H., Ishima, Y., Farghaly Aly, U., Sarhan, H.A., Ishida, T., Using Bio-Layer Interferometry to evaluate anti-PEG antibody-mediated complement activation. Biol. Pharm. Bull., 45, 129-135 (2022)
  12. Ibrahim, M., Ramadan, E., Elsadek, N.E., Emam, S.E., Shimizu, T., Ando, H., Ishima, Y., Elgarhy, O.H., Sarhan, H.A., Hussein, A.K., Ishida, T., Polyethylene glycol (PEG): The nature, immunogenicity, and role in the hypersensitivity of PEGylated products. J. Control. Release, 351, 215-230 (2022)
  13. Matsuo, N., Ando, H., Doi, Y., Shimizu, T., Ishima, Y., Ishida, T., The challenge to deliver oxaliplatin (l-OHP) to solid tumors: development of liposomal l-OHP formulations. Chem. Pharm. Bull. 70, 351-358 (2022)
  14. Ishima, Y., Maruyama, T., Otagiri, M., Chuang, V., Ishida, T., The new delivery strategy of albumin carrier utilizing the interaction with albumin receptors. Chem. Pharm. Bull. 70, 330-333 (2022)
  15. Shimizu, T., Kawaguchi, Y., Ando, H., Ishima, Y., Ishida, T., Development of an antigen delivery system for a B cell-targeted vaccine as an alternative to dendritic cell-targeted vaccines. Chem. Pharm. Bull., 70, 341-350 (2022)
  16. 異島優、小田切優樹、石田竜弘、アルフ?ミンのホ?リスルフィト?による新たな生体恒常性維持機構、人工血液、30、59-64 (2022)
  17. 安藤英紀、脾臓標的DDS技術を利用して刷新的な抗体を誘導する新規免疫技術の開発～第14回日本DDS学会奨励賞（基礎）によせて～、Drug Delivery System、37、334-340 (2022)
  18. 清水太郎、石田竜弘、中分子創薬に向けたDDS開発の新展開（杉林堅次 監修）、第26章 中分子医薬品やDDSに対する免疫応答、231-239 (2022)
  19. Giuseppe Curigliano, 松村保広、石田竜弘、最新の免疫腫瘍微小環境の理解とADC, DDSの革新的イノベーション、がん分子標的治療、19、47-55 (2022)

研究费获得状况

  1. 科学研究费补助金「挑戦的研究（萌芽）」（新规）
  2. 高桥产业経済研究财団「研究助成金」（新规）
  3. 日本科学协会「笹川科学研究助成金」（新规）
  4. 桥渡し研究戦略的推进プログラム?研究开発シーズ础（新规）
  5. 狈贰顿翱「官民による若手研究者発掘支援事业／マッチングサポートフェーズ」（新规）
  6. 中谷医工计测技术振兴财団「技术开発研究助成」（新规）
  7. 日本医疗研究开発机构（础惭贰顿）「创薬基盘推进研究事业」（継続）
  8. 日本医疗研究开発机构（础惭贰顿）「先端的バイオ创薬等基盘技术开発事业」（継続）
  9. 科学研究费补助金「学术変革领域研究础（计画研究）」（継続）
  10. 科学研究费补助金「学术変革领域研究础（公募研究）」（継続）
  11. 科学研究费补助金「挑戦的研究（萌芽）」（継続）
  12. 狈贰顿翱「官民による若手研究者発掘支援事业／共同研究フェーズ」（継続）
  13. 科学研究费补助金「基盘叠」（継続）
  14. 科学研究费补助金「基盘叠」（継続）
  15. 科学研究费补助金「特别研究员奨励费」（継続）
  16. 喫烟科学研究财団「研究助成金」（継続）
  17. 科学技术振兴机构?研究成果最适展开支援プログラム（础-厂罢贰笔）产学共同（育成型）（継続）
  18. 科学研究费补助金「特别研究员（外国人）奨励费」（継続）
  19. 科学研究费补助金「国际共同研究强化叠」（継続）

2021年度

  1. Ohashi, E., Karanjit, S., Nakayama, A., Takeuchi, K., Emam, S., Ando, H., Ishida, T., Namba, K., Efficient Construction of the Hexacyclic Ring Core of Palau’amine: The pKa Concept for Proceeding with Unfavorable Equilibrium Reactions. Chem. Sci., 12, 12201-12210 (2021)
  2. Saito, K., Shimizu, T., Suzuki?Inoue, K., Ishida, T., Wada, Y., Aseptic meningitis after vaccination of the BNT162b2 mRNA COVID?19 vaccine. Neurol. Sci. (2021)
  3. Kinoshita, R., Ishima, Y., Chuang, V., Watanabe, H., Shimizu, T., Ando, H., Okuhira, K., Otagiri, M., Ishida, T., Maruyama, T., The therapeutic effect of HSA dimer-doxorubicin complex against human pancreatic tumour. Pharmaceutics, 13, 1209 (2021)
  4. Mogi, K., Kamiya, I., Makino, A., Hirao, A., Abe, R., Doi, Y., Shimizu, T., Ando, H., Morito, K., Takayama, K., Ishida, T., Nagasawa, K., Liposomalization of oxaliplatin exacerbates the non-liposomal formulation-induced decrease of sweet taste sensitivity in rats. J. Pharm. Sci., 110, 3937-3945 (2021)
  5. Ando, H., Mochizuki, T., Abu Lila, A.S., Akagi, S., Tajima, K., Fujita, K., Shimizu, T., Ishima, Y., Matsushima, T., Kusano, T., Ishida, T., Doxorubicin embedded into nanofibrillated bacterial cellulose (NFBC) produces a promising therapeutic outcome for peritoneally metastatic gastric cancer in mice models via intraperitoneal direct injection. Nanomaterials, 11, 1697 (2021)
  6. Ando, H., Murakami, Y., Eshima, K., Ishida, T., A novel polyethylene glycol (PEG)-drug conjugate of Venetoclax, a Bcl-2 inhibitor, for treatment of acute myeloid leukemia (AML). Cancer Reports, e1485 (2021)
  7. Emam, S.E., Elsadek, N.E., Abu Lila, A.S., Takata, H., Kawaguchi, Y., Shimizu, T., Ando, H., Ishima, Y., Ishida, T., Anti-PEG IgM production and accelerated blood clearance phenomenon after the administration of PEGylated exosomes in mice. J. Control. Release, 334, 327-334 (2021)
  8. Qelliny, M., Shimizu, T., Elsadek, N., Emam, S., Takata, H., Fathalla, Z., Hussein, A., Khaled, K., Ando, H., Ishima, Y., Ishida, T., Incorporating gangliosides into PEGylated cationic liposomes that complexed DNA attenuates anti-PEG antibody production, but not anti-DNA antibody production in mice. Mol. Pharmaceut., 18, 2406-2415 (2021)
  9. Hama, M., Ishima, Y., Chuang, V., Ando, H., Shimizu, T., Ishida, T., Evidence for delivery of Abraxane® via a denatured-albumin transport system. ACS Applied Materials & Interfaces, 13, 19736-19744 (2021)
  10. Ando, H., Emam, S.E., Kawaguchi, Y., Shimizu, T., Ishima, Y., Eshima, K., Ishida, T., Increasing tumor extracellular pH by an oral alkalinizing agent improves antitumor responses of anti-PD-1 antibody: Implication of relationships between serum bicarbonate concentrations, urinary pH, and therapeutic outcomes. Biol. Pharm. Bull., 44, 844-852 (2021)
  11. Hirakawa, N., Ishima, Y., Kinoshita, R., Nakano, R., Chuang, VTG., Ando, H., Shimizu, T., Okuhira, K., Maruyama, T., Otagiri, M., Ishida, T., Reduction-responsive and Multi-drug Deliverable Albumin Nanoparticles: an antitumor drug to Abraxane® against Human Pancreatic Tumor-Bearing Mice. ACS Applied Bio Materials, 4, 4302-4309 (2021)
  12. Takata, H., Shimizu, T., Kawaguchi, Y., Ueda, H., Elsadek, N.E., Ando, H., Ishima, Y., Ishida, T., Nucleic acids delivered by PEGylated cationic liposomes in systemic lupus erythematosus-prone mice: a possible exacerbation of lupus nephritis in the presence of pre-existing anti-nucleic acid antibodies. Int. J. Pharm., 601, 120529 (2021)
  13. Akagi, S., Ando, H., Fujita, K., Shimizu, T., Ishima, Y., Tajima, K., Matsushima, T., Kusano, T., Ishida, T., Therapeutic efficacy of a paclitaxel-loaded nanofibrillated bacterial cellulose (PTX/NFBC) formulation in a peritoneally disseminated gastric cancer xenograft model. Int. J. Biol. Macromol., 174, 494-501 (2021)
  14. Shimizu, T., Watanabe, Y., Ando, H., Ishima, Y., Ishida, T., Lymphoid follicle antigen (Ag) delivery and enhanced rodent humoral immune responses mediated by Ag-containing PEGylated liposomes. Vaccine, 39, 1131-1139 (2021)
  15. Ando, H., Eshima, K., Ishida, T., Neutralization of acidic tumor microenvironment (TME) with daily oral dosing of sodium potassium citrate (K/Na Citrate) increases therapeutic effect of anti-cancer agent in pancreatic cancer xenograft mice model. Biol. Pharm. Bull., 44, 266-270 (2021)
  16. Shimizu, T., Awata, M., Abu Lila, A.S., Yoshioka, C., Kawaguchi, Y., Ando, H., Ishima, Y., Ishida, T., Complement activation induced by PEG enhances humoral immune responses against antigens encapsulated in PEG-modified liposomes. J. Control. Release, 329, 1046-1053 (2021)
  17. 安藤英紀、DDS抗がん剤の腫瘍内局在の解明と腫瘍微小環境改善による効果増強、薬学雑誌, 141, 1241-1245 (2021)
  18. 田島健次、松島得雄、小瀬亮太、藤田彩華、甲野裕之、安藤英紀、石田竜弘、セルロースナノファイバー 研究と実用化の最前線（矢野浩之、磯貝明、北川和男 監修）　第1編 第1章 第1節ナノフィブリル化バクテリアセルロースの生産とその応用 (2021)
  19. 清水太郎、石田竜弘、創薬研究者?アカデミア研究者が知っておくべき最新の免疫学とその応用技術、第6章第1節 タンパクやナノ粒子に対するPEG修飾の有用性と免疫系に与える影響、475-483 (2021)
  20. 石田竜弘、安藤英紀、実践 製剤学～そしてその基盤となる物理薬剤学～（飯村菜穂子、萩原琢男 編） 第11章 ドラッグデリバリーシステム（DDS）、447-471 第3版(2021)

研究费获得状况

  1. 日本医疗研究开発机构（础惭贰顿）「创薬基盘推进研究事业」（新规）
  2. 日本医疗研究开発机构（础惭贰顿）「先端的バイオ创薬等基盘技术开発事业」（新规）
  3. コーセーコスメトロジー研究财団「研究助成金」（新规）
  4. 科学研究费补助金「学术変革领域研究础（计画研究）」（新规）
  5. 科学研究费补助金「学术変革领域研究础（公募研究）」（新规）
  6. 科学研究费补助金「挑戦的研究（萌芽）」（新规）
  7. 狈贰顿翱「官民による若手研究者発掘支援事业／共同研究フェーズ」（新规）
  8. 科学研究费补助金「基盘叠」（新规）
  9. 科学研究费补助金「基盘叠」（新规）
  10. 科学研究费补助金「特别研究员奨励费」（新规）
  11. 日本科学协会「笹川科学研究助成金」（新规）
  12. 喫烟科学研究财団「研究助成金」（新规）
  13. 桥渡し研究戦略的推进プログラム?研究开発シーズ础（新规）
  14. ヤクルト?バイオサイエンス研究财団「研究助成金」（新规）
  15. 科学技术振兴机构?研究成果最适展开支援プログラム（础-厂罢贰笔）产学共同（育成型）（継続）
  16. 科学研究费补助金「特别研究员（外国人）奨励费」（継続）
  17. 科学研究费补助金「挑戦的研究（萌芽）」（継続）
  18. 科学研究费补助金「国际共同研究强化叠」（継続）
  19. 科学研究费补助金「基盘颁」（継続）

2020年度

  1. Takayama, T., Shimizu, T., Abu Lila, A., Kanazawa, Y., Ando, H., Ishima, Y., Ishida, T., Adjuvant antitumor immunity contributes to the overall antitumor effect of PEGylated liposomal doxorubicin (Doxil®) in C26 tumor-bearing immunocompetent mice. Pharmaceutics, 12, 990 (2020)
  2. Fujimoto, S., Muguruma, N., Nakao, M., Ando, H., Kashihara, T., Miyamoto, Y., Okamoto, K., Sano, S., Ishida, T., Sato, Y., Takayama, T., Indocyanine green-labeled dasatinib as a new fluorescent probe for molecular imaging of gastrointestinal stromal tumors. J. Gastroenterol. Hepatol. (2020)
  3. Suzuki, T., Suzuki, Y., Hihara, T., Kubara, K., Kondo, K., Hyodo, K., Yamazaki, K., Ishida, T., Ishihara, H., PEG shedding-rate-dependent blood clearance of PEGylated lipid nanoparticles in mice: faster PEG shedding attenuates anti-PEG IgM production. Int. J. Pharm., 588, 119792 (2020)
  4. Nguyen, A., Ando, H., Böttger, R., Viswanadham, K. K., Rouhollahi, E., Ishida, T., Li, S., Utilization of Click Chemistry to Study the Effect of Poly(ethylene) Glycol Molecular Weight on the Self-Assembly of PEGylated Gambogic Acid Nanoparticles for the Treatment of Rheumatoid Arthritis. Biomater. Sci. 8, 4626-4637 (2020)
  5. Elsadek, N.E., Hondo, E., Shimizu, T., Takata, H., Abu Lila, A.S., Emam, S., Ando, H., Ishima, Y., Ishida, T., Impact of pre-existing or induced anti-PEG IgM on the pharmacokinetics of peginterferon alfa-2a (Pegasys®) in mice. Mol. Pharmaceut., 17, 2964-2970 (2020)
  6. Tsukigawa, K., Imoto S., Yamasaki, K., Nishi, K., Tsutsumi, T., Yokoyama, S., Ishima, Y., Otagiri, M., Synthesis and In Vitro Assessment of pH-Sensitive Human Serum Albumin Conjugates of Pirarubicin. Pharmaceuticals (Basel)., 14, 22 (2020)
  7. Tanaka, R., Imafuku, T., Suzuki, Y., Nishida, K., Matsusaka, K., Shin, T., Sato, Y., Ishima, Y., Watanabe, H., Mimata, H., Maruyama, T., Itoh, H., Changes in redox state of albumin before and after kidney transplantation in patients with end-stage renal disease. Clin Biochem., 81, 20-26 (2020)
  8. Elsadek, N.E., Emam, S.E., Abu Lila, A.S., Shimizu, T., Ando, H., Ishima, Y., Ishida, T., Pegfilgrastim (PEG-G-CSF) induces anti-polyethylene glycol (PEG) IgM via a T cell- dependent mechanism. Biol. Pharm. Bull., 43, 1393-1397 (2020)
  9. Ryujin, T., Shimizu, T., Miyahara, R., Asai, D., Shimazui, R., Yoshikawa, T., Kishimura, A., Mori, T., Ishida, T., Katayama, Y., Blood retention and antigenicity of polycarboxybetaine-modified liposomes. Int. J. Pharma., 586, 119521 (2020)
  10. Oh, Y., Niijima, H., Kawahara, Y., Hayase, T., Shimizu, T., Ishida, T., Morimoto, A., An immediate hypersensitivity reaction induced by PEGylated recombinant factor Ⅷ. Haemophilia (2020)
  11. Elsadek, N.E., Abu Lila, A.S., Emam, S.E., Shimizu, T., Takata, H., Ando, H., Ishima, Y., Ishida, T., Pegfilgrastim (PEG-G-CSF) induces anti-PEG IgM in a dose dependent manner and causes the accelerated blood clearance (ABC) phenomenon upon repeated administration in mice. Eur. J. Pharm. Biopharm., 152, 56-62 (2020)
  12. Ando, H., Saito-Tarashima, N., Abu Lila, A. S., Kinjo, N., Shimizu, T., Ishima, Y., Minakawa, N., Ishida, T., A unique gene-silencing approach, using an intelligent RNA expression device (iRed), results in minimal immune stimulation when given by local intrapleural injection in malignant pleural mesothelioma. Molecules, 25, 1725 (2020)
  13. El Sayed, M.M., Takata, H., Shimizu, T., Kawaguchi, Y., Abu Lila, A.S., Elsadek, N.E., Alaaeldin, E., Ishima, Y., Ando, H., Kamal, A., Sarhan, H.A., Ishida, T., Hepatosplenic phagocytic cells indirectly contribute to anti-PEG IgM production in the accelerated blood clearance (ABC) phenomenon against PEGylated liposomes: Appearance of an unexplained mechanism in the ABC phenomenon. J. Control. Release, 323, 102-109 (2020)
  14. Oniki, K., Nohara, H., Nakashima, R., Obata, Y., Muto, N., Sakamoto, Y., Ueno-Shuto, K., Imafuku, T., Ishima, Y., Watanabe, H., Maruyama, T., Otake, K., Ogata, Y., Suico, M.A., Kai, H,. Shuto, T., Saruwatari, J., The DsbA-L gene is associated with respiratory function of the elderly via its adiponectin multimeric or antioxidant properties. Sci Rep., 10, 5973 (2020)
  15. Torao, T., Mimura, M., Oshima, Y., Fujikawa, K., Hasan, M., Shimokawa, T., Yamazaki, N., Ando, H., Ishida, T., Fukuta, T., Tanaka, T., Kogure, K., Characteristics of unique endocytosis induced by weak current for cytoplasmic drug delivery, Int. J. Pharm., 576, 119010 (2020)
  16. Taguchi, K., Ogaki, S., Nagasaki, T., Yanagisawa, H., Nishida, K., Maeda, H., Enoki, Y., Matsumoto, K., Sekijima, H., Ooi, K., Ishima, Y., Watanabe, H., Fukagawa, M., Otagiri, M., Maruyama, T., Carbon Monoxide Rescues the Developmental Lethality of Experimental Rat Models of Rhabdomyolysis-Induced Acute Kidney Injury. J Pharmacol Exp Ther., 372, 355-365 (2020)
  17. Maeda, H., Minayoshi, Y., Ichimizu, S., Mizuta, Y., Nagasaki, T., Matsusaka, K., Oshiro, S., Oniki, K., Saruwatari, J., Ishima, Y., Watanabe, H., Otagiri, M., Maruyama, T., Repeated Administration of Kupffer Cells-Targeting Nanoantioxidant Ameliorates Liver Fibrosis in an Experimental Mouse Model. Biol Pharm Bull., 43, 93-101 (2020)
  18. Ishima, Y., Minomo, A., Tuan Giam Chuang, V., Fukuda, T., Kusumoto, K., Okuhira, K., Suwa, Y., Watanabe, H., Ishida, T., Morioka, H., Maruyama, T., Otagiri, M., Albumin domain mutants with enhanced Aβ binding capacity identified by phage display analysis for application in various peripheral Aβ elimination approaches of Alzheimer's disease treatment. IUBMB Life, 72, 641-651 (2020)
  19. Koba, R., Fujita, H., Nishibori, M., Saeki, K., Nagayoshi, K., Sadakari, Y., Nagai, S., Sekizawa, O., Nitta, K., Manabe, T., Ueki, T., Ishida, T., Oda, Y., Nakamura, M., Quantitative evaluation of the intratumoral distribution of platinum in oxaliplatin-treated rectal cancer: In situ visualization of platinum via synchrotron radiation X-ray fluorescence spectrometry. Int. J. Cancer., 146, 2498-2509 (2020)
  20. Ando, H., Ishida, T., An RNAi therapeutic, DFP-10825, for intraperitoneal and intrapleural malignant cancers. Adv. Drug Deliv. Review, 154-155, 27-36 (2020)
  21. Kozma, G., Shimizu, T., Ishida, T., Szebeni, J., Anti-PEG antibodies: Properties, formation and role in adverse immune reactions to PEGylated nano-biopharmaceuticals. Adv. Drug Deliv. Review, 154-155, 163-175 (2020)
  22. Ishima, Y., Maruyama, T., Otagiri, M., Ishida, T., Drug Delivery System for Refractory Cancer Therapy via an Endogenous Albumin Transport System. Chem Pharm Bull (Tokyo)., 68, 583-588 (2020)
  23. Ishida, T., Kawakami, S., Hosoya, K., Foreward in Recent advances in research on particulate formulations such as lipoproteins, liposomes, extracellular vesicles, and iPS-derived cells. Biol. Pharm. Bull. 43, 575 (2020)
  24. Harashima, H., Ishida, T., Editorial: Advanced Liposome Research. Adv Drug Deliv Rev., 154-155, 1 (2020)
  25. 清水太郎、異島優、石田竜弘、タンパクのPEG修飾によるPEG免疫応答の誘導、薬学雑誌、140, 163-169 (2020)
  26. 安藤英紀、石田竜弘、臨床応用可能な体腔内投与型RNAi 製剤（DFP-10825）の開発と難治性がんに対する治療、MEDCHEM NEWS, 30, 19-24 (2020)
  27. 安藤英紀、清水太郎、石田竜弘、リポソームDDS 製剤開発における免疫系の制御と動態解析の重要性、オレオサイエンス, 20, 71-76 (2020)

研究费获得状况

  1. 科学研究费补助金「特别研究员（外国人）奨励费」（新规）
  2. 持田记念医学薬学振兴财団「研究助成金」（新规）
  3. 科学技术振兴机构?研究成果最适展开支援プログラム（础-厂罢贰笔）产学共同（育成型）（新规）
  4. 科学研究费补助金「挑戦的研究（萌芽）」（新规）
  5. 金原一郎记念医学医疗振兴财団「研究交流助成金」（新规）
  6. 日本科学协会「笹川科学研究助成金」（新规）
  7. 科学研究费补助金「国际共同研究强化叠」（継続）
  8. 科学研究费补助金「基盘颁」（継続）
  9. 科学研究费补助金「若手研究」（継続）
  10. 科学研究费补助金「基盘叠」（継続）

2019年度

  1. Emam, S., Abu Lila, A., Elsadek, N., Ando, H., Shimizu, T., Okuhira, K., Ishima, Y., Mahdy, M., Ghazy, E., Ishida, T., Cancer cell-type tropism is one of crucial determinants for the efficient systemic delivery of cancer cell-derived exosomes to tumor tissues. Eur. J. Pharm. Biopharm., 145, 27-34 (2019)
  2. Ando, H., Fukushima, M., Eshima, K., Hasui, T., Shimizu, T., Ishima, Y., Huang, C., Wada, H., Ishida, T., A novel intraperitoneal therapy for gastric cancer with DFP-10825, a unique RNAi therapeutic targeting thymidylate synthase, in peritoneally disseminated xenograft model. Cancer Med., 8, 7313-7321 (2019)
  3. Ichimizu, S., Watanabe, H., Maeda, H., Hamasaki, K., Ikegami, K., Chuang, V., Kinoshita, R., Nishida, K., Shimizu, T., Ishima, Y., Ishida, T., Seki, T., Katsuki, H., Futaki, S., Otagiri, M., Maruyama, T., Cell-penetrating mechanism of intracellular targeting albumin: Contribution of macropinocytosis induction and endosomal escape. J. Control. Release, 304, 156-163 (2019)
  4. Ikeda, M., Ishima, Y., Chuang, VTG., Sakai, M., Osafune, H., Ando, H., Shimizu, T., Okuhira, K., Watanabe, H., Maruyama, T., Otagiri, M., Akaike, T., Ishida, T., Distribution of Polysulfide in Human Biological Fluids and Their. Association with Amylase and Sperm Activities. Molecules, 24, 1689 (2019)
  5. Ando, H., Abu Lila, A., Fukushima, M., Matsuoka, E., Shimizu, T., Okuhira, Y., Ishima, Y., Huang, C., Wada, H., Ishida, T., A simplified method for manufacturing RNAi therapeutics for local administration. Int. J. Pharm., 564, 256-262 (2019)
  6. Doi, Y., Shimizu, T., Ishima, Y., Ishida, T., Long-term storage of PEGylated liposomal oxaliplatin with improved stability and long circulation times in vivo. Int. J. Pharm., 564, 237-243 (2019)
  7. Kawahara, H., Miyashita, N., Tachibana, K., Tsuda, Y., Morimoto, K., Tsuji, K., Shigenaga, A., Otaka, A., Ishida, T., Okuhira, K., A photo-activatable peptide mimicking functions of apolipoprotein A-I. Biol. Pharm. Bull., 42, 1019-1024 (2019)
  8. Ishima, Y., Watanabe, K., Chuang, V., Takeda, I., Kuroda, T., Ogawa, W., Watanabe, H., Iwao. Y., Ishida, T., Otagiri, M., Maruyama, T., S-Nitrosated alpha-1-acid glycoprotein exhibits antibacterial activity against multidrug-resistant bacteria strains and synergistically enhances the effect of antibiotics. FASEB BioAdvances., 1, 137-150 (2019)
  9. Mohamed, M., Abu Lila, A.S., Shimizu, T., Alaaeldin, E., Hussein, A., Sarhan, H., Szebeni, J., Ishida, T., PEGylated liposomes: immunological responses. Sci. Technol. Adv. Mater., 20, 710-724 (2019)
  10. Abu Lila, A.S., Ishida, T., Anti-PEG IgM production via a PEGylated nano-carrier system for nucleic acid delivery. in Nanotechnology for Nucleic acid Delivery (2nd Edition), Methods in Molecular Biology, Oupicky, D. and Ogris, M. (Ed.), Springer, 1943, 333-346 (2019)
  11. Elsadek, N.E., Abu Lila, A.S., Ishida, T., Immunogenicity against PEGylated proteins, in Polymer-protein conjugates: From PEGylation and beyond (Chapter 5), Pasut, G. and Zalipsky, S. (Ed.), Elsevier Inc., 103-123 (2019)
  12. Abu Lila, A.S., Ishida, T., The accelerated blood clearance (ABC) phenomenon of PEGylated nanocarriers. Pan Stanford Publishing, A book chapter in Immune Aspects of Biopharmaceuticals and Nanomedicines, Chapter 7, 249-287 (2019)
  13. Abu Lila, A.S., Ishida, T., Anti-PEG immunity against PEGylated therapeutics. Pan Stanford Publishing, A book chapter in Immune Aspects of Biopharmaceuticals and Nanomedicines, Chapter 8, 289-309 (2019)
  14. Abu Lila, A.S., Janos. S., Ishida, T., Accelerated blood clearance phenomenon and complement activation-related pseudoallergy: two sides of the same coin. Pan Stanford Publishing, A book chapter in Immune Aspects of Biopharmaceuticals and Nanomedicines, Chapter 25, 771-800 (2019)
  15. 関陽介、植野美彦、澤田麻衣子、石田竜弘、入学者選抜の評価を支援する分散評価システムの開発と導入 ―薬学部AO入試における書類審査での活用事例から―、大学入試研究ジャーナル、29, 217－222 (2019)
  16. 清水太郎、安藤英紀、異島優、石田竜弘、PEG修飾リポソームに対する免疫応答、人工血液、27, 37-43 (2019)
  17. 安藤英紀、田島健次、松島得雄、石田竜弘、ナノフィブリル化バクテリアセルロース(Fibnano)を用いた腹腔内投与型がん治療製剤への応用、Cellulose Communications, 26, 173-177 (2019)
  18. 田島健次、小瀬亮太、松島得雄、石田竜弘、安藤英紀、フルーツ由来新奇酢酸菌によるナノセルロースの合成とその応用、日本醸造協会誌, 114, 540-549 (2019)
  19. 田島健次、小瀬亮太、石田竜弘、松島得雄、セルロースナノファイバー製造?利用の最新動向（宇山浩 監修） 第1編 製造と評価 第6章 発酵ナノセルロースの大量生産とその応用、57－66 (2019)

研究费获得状况

  1. 科学研究费补助金「国际共同研究强化叠」（新规）
  2. 高桥产业経済研究财団「研究助成金」（新规）
  3. 科学研究费补助金「基盘颁」（新规）
  4. 科学研究费补助金「若手研究」（新规）
  5. 永井記念薬学国際交流財団「Pre-Doctoral Fellowship」（新規）
  6. 科学研究费补助金「挑戦的萌芽研究」（継続）
  7. 科学研究费补助金「特别研究员奨励费」（継続）
  8. 科学研究费补助金「基盘叠」（継続）
  9. 科学研究费补助金「国际共同研究加速基金」（継続）

2018年度

  1. Shimizu, T., Abu Lila, A.S., Awata, M., Kubo, Y., Mima, Y., Hashimoto, Y., Ando, H., Okuhira, K., Ishima, Y., Ishida, T., A cell assay for detecting anti-PEG immune response against PEG-modified therapeutics. Pharm. Res., 35, 223 (2018)
  2. Emam, S., Ando, H., Abu Lila, A.S., Shimizu, T., Okuhira, K., Ishima, Y., Mahdy, M., Ghazy, F., Sagawa, I., Ishida, T., Liposome co-incubation with cancer cells secreted exosomes (extracellular vesicles) with different proteins expressions and different uptake pathways. Sci. Rep., 8, 14493 (2018)
  3. Shimizu, T., Abu Lila, A.S., Kawaguchi, Y., Shimazaki, Y., Watanabe, Y., Mima, Y., Hashimoto, Y., Okuhira, K., Storm, G., Ishima, Y., Ishida, T., A novel platform for cancer vaccine: Antigen-selective delivery to splenic marginal zone B cells via repeated injections of PEGylated liposomes. J. Immunol., 201, 2969-2976 (2018)
  4. Mészáros, T., Kozma, G., Shimizu, T., Miyahara, K., Turjeman, K., Ishida, T., Barenholz, Y., Urbanics, R., Szebeni, J., Involvement of complement activation in the pulmonary vasoactivity of polystyrene nanoparticles in pigs: Unique surface properties underlying alternative pathway activation and instant opsonization. Int. J. Nanomed., 13, 6345-6357 (2018)
  5. Minayoshi, Y., Maeda, H., Yanagisawa, H., Hamasaki, K., Mizuta, Y., Nishida, K., Kinoshita, R., Enoki, Y., Imafuku, T., Chuang, V.T.G., Koga, T., Fujiwara, Y., Takeya, M., Sonoda, K., Wakayama, T., Taguchi, K., Ishima, Y., Ishida, T., Iwakiri, Y., Tanaka, M., Sasaki, Y., Watanabe, H., Otagiri, M., Maruyama, T., Development of Kupffer cell targeting type-I interferon for the treatment of hepatitis via inducing anti-inflammatory and immunomodulatory actions. Drug Deliv., 25, 1067-1077 (2018)
  6. Emam, S.E., Ando, H., Abu Lila, A.S., Kobayashi, S., Shimizu, T., Okuhira, K., Ishima, Y., Ishida, T., Doxorubicin expands in vivo secretion of circulating exosome in mice. Biol. Pharm. Biol., 41, 1078-1083 (2018)
  7. Shimizu, T., Abu Lila, A.S., Fujita, R., Awata, M., Kawanishi, M., Hashimoto, Y., Okuhira, K., Ishima, Y., Ishida, T., A hydroxyl PEG version of PEGylated liposomes and its impact on anti-PEG IgM induction and on the accelerated clearance of PEGylated liposomes. Eur. J. Pharm. Biopharm., 127, 142-149 (2018)
  8. Emam, S.E., Ando, H., Abu Lila, A.S., Shimizu, T., Ukawa, M., Okuhira, K., Ishima, Y., Mahdy, M.A., Ghazy, F.S., Ishida, T., A novel strategy to increase the yield of exosomes (extracellular vesicles) for an expansion of basic research. Biol. Pharm. Bull., 41, 733-742 (2018)
  9. Afroz, S., Yagi, A., Fujikawa, K., Rahman, M., Morito, K., Fukuta, T., Watanabe, S., Kiyokage, E., Toida, K., Shimizu, T., Ishida, T., Kogure, K., Tokumura, A., Tanaka, T., Lysophosphatidic acid in medicinal herbs protects against indomethacin-induced gastric cell damage in vivo and in vitro. Prostaglandins & Other Lipid Mediators, 135, 36-44 (2018)
  10. Ando, H., Abu Lila, A.S., Tanaka, M., Doi, Y., Terada, Y., Yagi, N., Shimizu, T., Okuhira, K., Ishima, Y., Ishida, T., Intratumoral visualization of oxaliplatin within a liposomal formulation using X-ray fluorescence spectrometry. Mol Pharm., 15, 403-409 (2018)
  11. Tanaka, K., Shimoda, M., Chuang,V., Nishida, K., Kawahara, M., Ishida, T., Otagiri, M., Maruyama, T., Ishima, Y., Thioredoxin-Albumin Fusion Protein Prevents Copper enhanced Zinc-induced Neurotoxicity via Its Antioxidative activity. Int J Pharm, 535, 140-147 (2018)
  12. Ikeda, M., Ishima, Y., Kinoshita, R., Chuang, V., Tasaka, N., Matsuo, N., Watanabe, H., Shimizu, T., Ishida, T., Otagiri, M., Maruyama, T., A Novel S-Sulfhydrated Human Serum Albumin Preparation Suppresses Melanin Synthesis, Redox Biology, 14, 354-360 (2018)
  13. Ando, H., Abu Lila, A.S., Kawanishi, M., Shimizu, T., Okuhira, K., Ishima, Y., Ishida, T., Reactivity of IgM antibodies elicited by PEGylated liposomes or PEGylated lipoplexes against auto and foreign antigens. J. Control. Release, 270, 114-119 (2018)
  14. Oshiro S, Ishima Y, Hitoshi M, Honda N, Jing B, Kinoshita R, Ikeda M, Iwao Y, Imafuku T, Nishida K, Miyamura S, Watanabe H, Otagiri M, Maruyama T. Dual Therapeutic Effects of an Albumin-based Nitric Oxide Donor on Two Experimental Models of Chronic Kidney Disease. J Pharm Sci. 107, 848-855 (2018)
  15. Abu Lila, A.S., Ishida, T., Immune response to PEGylated nanomedicines: Impact of IgM Response. The Springer International Publishing AG. A book chapter in Radionanomedicine, Chapter 20, 371-390 (2018)
  16. Abu Lila, A.S., Shimizu, T., Ishida, T., PEGylation and anti-PEG antibodies. Pan Stanford Publishing, A book chapter in Engineering of Biomaterials for Drug Delivery Systems, Beyond Polyethylene Glycol, Chapter 3, 51-68 (2018)
  17. 田島健次、小瀬亮太、石田竜弘、松島得雄、発酵ナノセルロース（NFBC）の大量生産とその医療応用、BIO INDUSTRY、35, 55-63 (2018)
  18. 安藤英紀、石田竜弘、放射光施設（SPring-8）における蛍光X線分析法を用いたオキサリプラチン腫瘍内分布解析、薬剤学、78, 28-33 (2018)
  19. 石田竜弘、生体内動態の理解を基盤としたリポソームDDSの開発～臨床応用を目指して～ 第11回日本DDS学会水島賞によせて、Drug Deliv. Sys., 33, 318-328 (2018)
  20. 異島優、丸山徹、石田竜弘、小田切優樹、内因性アルブミン輸送システムを利用した腫瘍選択的NO供与によるEPR効果の制御、Drug Deliv. Sys., 33, 130-138 (2018)

研究费获得状况

  1. 日本学术振兴会外国人特别研究员（闯厂笔厂サマー?プログラム）调査研究费（新规）
  2. 平成30年度徳岛大学産学連携研究者育成支援事業（タイプA）（新規）
  3. 科学研究费补助金「挑戦的萌芽研究」（新规）
  4. 科学研究费补助金「特别研究员奨励费」（新规）
  5. 叁岛海云记念财団「学术研究奨励金」（新规）
  6. 高桥产业経済研究财団「研究助成金」（継続）
  7. 科学研究费补助金「基盘叠」（新规）
  8. 永井记念薬学国际交流财団「研究助成金」（新规）
  9. 橋渡し研究?新規開発シーズ（シーズA 岡山大学拠点）（新規）
  10. 平成28年度戦略的基盘技术高度化支援事业（継続）
  11. 科学研究费补助金「国际共同研究加速基金」（継続）
  12. 科学研究费补助金「若手叠」（継続）
  13. 科学研究费补助金「若手叠」（継続）

2017年度

  1. Nishida, K., Kashiwagi, M., Shiba, S., Muroki, K., Ohishi, A., Doi, Y., Ando, H., Ishida, T., Nagasawa, K., Liposomalization of oxaliplatin induces skin accumulation of it, but negligible skin toxicity. Toxicol. Appl. Pharmacol., 337, 76-84 (2017)
  2. Kinoshita, R., Ishima, Y., Chuang, V., Nakamura, H., Fang, J., Watanabe, H., Shimizu, T., Okuhira, K., Ishida, T., Maeda, H., Otagiri, M., Maruyama, T., Improved anticancer effects of albumin-bound paclitaxel nanoparticle via augmentation of EPR effect and albumin-protein interactions using S-Nitrosated Human Serum Albumin Dimer. Biomaterials, 140, 162-169 (2017)
  3. Shimizu, T., Abu Lila, A.S., Nishio, M., Doi, Y., Ando, H., Ukawa, M., Ishima, Y., Ishida, T., Modulation of antitumor immunity contributes to the enhanced therapeutic efficacy of liposomal oxaliplatin in mouse model. Cancer Sci., 108, 1864-1869 (2017)
  4. Alaaeldin, E., Abu Lila, A.S., Ando, H., Fukushima, M., Huang, C., Wada, H., Sarhan, H.A., Khaled, K.A., Ishidaa, T., Co-administration of liposomal l-OHP and PEGylated TS shRNA-lipoplex: A novel approach to enhance anti-tumor efficacy and reduce the immunogenic response to RNAi molecules. J. Control. Release, 255, 210-217 (2017)
  5. Ikeda, M., Ishima, Y, Chuang, V., Ikeda, T., Kinoshita, R., Watanabe, H., Ishida, T., Otagiri, M., Maruyama, T., Apoptosis induction of Poly-S-nitrosated human serum albumin in resistant solid tumor under hypoxia can be restored by phosphodiesterase 5 inhibition. Nitric Oxide, 69, 28-34 (2017)
  6. Ikeda, M., Ishima, Y., Shibata, A., Chuang, V., Sawa, T., Ihara, H., Watanabe, H., Xian, M., Ouchi, Y., Shimizu, T., Ando, H., Ukawa, M., Ishida, T., Akaike, T., Otagiri, M., Maruyama, T., Quantitative determination of polysulfide in albumins, plasma proteins and biological fluid samples using a novel combined assays approach. Anal. Chim. Acta, 969, 18-25 (2017)
  7. Mima, Y., Abu Lila, A.S., Shimizu, T., Ukawa, M., Ando, H., Kurata, Y., Ishida, T., Ganglioside inserted into PEGylated liposome attenuates anti-PEG immunity. J. Control Release, 250, 20-26 (2017)
  8. Matsuda, T., Hiraoka, S., Urashim, H., Ogura, A., Ishida, T., Preparation of an ultrafine rebamipide ophthalmic suspension with high transparency. Biol. Pharm. Bull., 40, 665-674 (2017)
  9. Abu Lila, A.S., Moriyoshi, N., Fukushima, M., Huang, C., Wada, H., Ishida, T., Metronomic S-1 dosing and thymidylate synthase silencing have synergistic antitumor efficacy in a colorectal cancer xenograft model. Cancer Letters, 400, 223-231 (2017)
  10. Matsushita, S., Nishi, K., Iwao, Y., Ishima, Y., Watanabe, H., Taguchi, K., Yamasaki, K., Maruyama, T., Otagiri, M., Recombinant Human Serum Albumin Containing 3 Copies of Domain I, Has Significant in Vitro Antioxidative Capacity Compared to the Wild-Type. Biol. Pharm. Bull., 40, 1813-1817 (2017)
  11. Watanabe, H., Sugimoto, R., Ikegami, K., Enoki, Y., Imafuku, T., Fujimura, R., Bi, J., Nishida, K., Sakaguchi, Y., Murata, M., Maeda, H., Hirata, K., Jingami, S., Ishima, Y., Tanaka, M., Matsushita, K., Komaba, H., Fukagawa, M., Otagiri, M., Maruyama, T., Parathyroid hormone contributes to the down-regulation of cytochrome P450 3A through the cAMP/PI3K/PKC/PKA/NF-κB signaling pathway in secondary hyperparathyroidism. Biochem. Pharmacol., 145, 192-201 (2017)
  12. Enoki, Y., Watanabe, H., Arake, R., Fujimura, R., Ishiodori, K., Imafuku, T., Nishida, K., Sugimoto, R., Nagao, S., Miyamura, S., Ishima, Y., Tanaka, M., Matsushita, K., Komaba, H., Fukagawa, M., Otagiri, M., Maruyama, T., Potential therapeutic interventions for chronic kidney disease-associated sarcopenia via indoxyl sulfate-induced mitochondrial dysfunction. J. Cachexia Sarcopenia Muscle., 8, 735-747 (2017)
  13. Ishima, Y., Albumin-Based Nitric Oxide Traffic System for the Treatment of Intractable Cancers. Biol. Pharm. Bull., 40, 128-134 (2017)
  14. Sugimoto, R., Watanabe, H., Ikegami, K., Enoki, Y., Imafuku, T., Sakaguchi, Y., Murata, M., Nishida, K., Miyamura, S., Ishima, Y., Tanaka, M., Matsushita, K., Komaba, H., Fukagawa, M., Otagiri, M., Maruyama, T., Down-regulation of ABCG2, a urate exporter, by parathyroid hormone enhances urate accumulation in secondary hyperparathyroidism. Kidney Int., 91, 658-670 (2017)
  15. Abu Lila, A.S., Ishida, T., Metronomic chemotherapy and nanocarrier platforms. Cancer Letters., 400, 232-242 (2017)
  16. Abu Lila, A.S., Kiwada, H., Ishida, T., Liposomal delivery systems: design optimization and current applications. Biol. Pharm. Bull., 40, 1-10 (2017)
  17. 清水太郎、異島優、石田竜弘、Accelerated blood clearance (ABC) 現象における動物種差、Drug Deliv. Sys., 32, 396-401 (2017)
  18. 清水太郎、異島優、石田竜弘、ナノ粒子に対する補体活性化の功罪、Drug Deliv. Sys., 32, 199-207 (2017)
  19. 石田竜弘、パートナー薬剤学（原島秀吉、伊藤智夫、寺田勝英編） 第5章 ドラッグデリバリーシステム（DDS，薬物送達システム）、353－386（2017）

研究费获得状况

  1. ひらめき☆ときめきサイエンス～ようこそ大学の研究室へ～ KAKENHI（研究成果の社会還元?普及事業）（新規）
  2. 山田养蜂场「研究助成金」（新规）
  3. 武田科学振兴财団「研究助成金」（新规）
  4. テルモ生命科学芸术财団「小规模研究会助成金」（新规）
  5. 平成28年度戦略的基盘技术高度化支援事业（継続）
  6. 高桥产业経済研究财団「研究助成金」（継続）
  7. 科学研究费补助金「若手叠」（新规）
  8. 科学研究费补助金「挑戦的萌芽研究」（継続）
  9. 科学研究费补助金「基盘颁」（継続）
  10. 科学研究费补助金「国际共同研究加速基金」（継続）
  11. 大阪コミュニティ财団「研究助成金」（新规）
  12. 科学研究费补助金「基盘叠」（継続）
  13. 橋渡し研究?新規開発シーズ（シーズA 九州大学拠点）（新規）
  14. 橋渡し研究?新規開発シーズ（シーズA 九州大学拠点）（新規）

2016年度

  1. Abu Lila, A.S., Fukushima, M., Huang, C., Wada, H., Ishida, T., Systemically administered RNAi molecule sensitizes malignant pleural mesothelioma cells to pemetrexed therapy. Mol. Pharmaceut., 13, 3955-3963 (2016)
  2. Shibata, A., Ishima, Y., Ikeda, M., Sato, H., Imafuku, T., Chuang, V., Ouchi, Y., Abe, T., Watanabe, H., Ishida, T., Otagiri, M., Maruyama, T., Human Serum Albumin Hydropersulfide is a potent reactive oxygen species scavenger in oxidative stress conditions such as Chronic Kidney Disease. Biochim. Biophys. Res. Commun. 479, 578-583 (2016)
  3. Doi, Y., Abu Lila, A.S., Matsumoto, H., Okada, T., Shimizu, T., Ishida, T., Improvement of intratumor microdistribution of PEGylated liposome via tumor priming by metronomic S-1 dosing. Int. J. Nanomed., 11, 5573-5582 (2016)
  4. Takayama, T., Ukawa, M., Kanazawa, Y., Ando, H., Shimizu, T., Ishida, T., Hydrodynamic tail vein injection as a simple tool for yielding extended transgene expression in solid tumors. Biol. Pharm. Bull., 39, 1555-1558 (2016)
  5. Miwa, Y., Hamamoto H., Ishida, T., Lidocaine self-sacrificially improves the skin permeation of the acidic and poorly water-soluble drug etodolac via its transformation into an ionic liquid. Eur. J. Pharm. Biopharm., 102, 92-100 (2016)
  6. Abu Lila, A.S., Kato, C., Fukushima, M., Huang, C., Wada, H., Ishida, T., Downregulation of thymidylate synthase by RNAi molecules enhances the antitumor effect of pemetrexed in an orthotopic malignant mesothelioma xenograft mouse model. Int. J. Oncol., 48, 1399-1407 (2016)
  7. Essam Eldin, N., Abu Lila, A.S., Kawazoe, K., Elnahas, H.M., Mahdy, M.A., Ishida, T., Encapsulation in a rapid-release liposomal formulation enhances the anti-tumor efficacy of pemetrexed in a murine solid mesothelioma-xenograft model. Eur. J. Pharm. Sci., 81, 60-66 (2016)
  8. Ukawa, M., Fujiwara, Y., Ando, H., Shimizu, T., Ishida, T., Hepatic tumor metastases cause enhanced PEGylated liposome uptake by Kupffer cells. Biol. Pharm. Bull., 39, 215-220 (2016)
  9. Tarashima, N., Ando, H., Kojima, T., Kinjyo, N., Hashimoto, Y., Furukawa, K., Ishida, T., Minakawa, N., Gene silencing using 4'-thioDNA as an artificial template to synthesize short-hairpin RNA without inducing a detectable innate immune response. Mol. Ther. - Nucleic Acids, 5, e274 (2016)
  10. 清水太郎、石田竜弘、Poly(ethylene glycol)に対する抗体の特性、評価、抑制、Drug Deliv. Sys., 31, 300-307 (2016)
  11. 石田竜弘、安藤英紀、実践 製剤学～そしてその基盤となる物理薬剤学～（飯村菜穂子、萩原琢男 編） 第11章 ドラッグデリバリーシステム（DDS）、447-471 第2版(2016)

研究费获得状况

  1. 平成28年度戦略的基盘技术高度化支援事业（新规）
  2. 永井记念薬学国际交流财団「研究助成金」（新规）
  3. 高桥产业経済研究财団「研究助成金」（新规）
  4. 科学研究费补助金「若手叠」（新规）
  5. 科学研究费补助金「挑戦的萌芽研究」（新规）
  6. 科学研究费补助金「基盘颁」（継続）
  7. 日本科学协会「笹川科学研究助成金」（新规）
  8. 科学研究费补助金「国际共同研究加速基金」（新规）
  9. 上原记念生命科学财団「研究推进特别奨励金」（新规）
  10. 科学研究费补助金「基盘叠」（継続）
  11. 科学研究费补助金「若手研究叠」（継続）
  12. 科学研究费补助金「若手研究叠」（継続）

2015年度

  1. Nakamura, H., Abu Lila A.S., Nishio, M., Tanaka, M., Ando, H., Kiwada, H., Ishida, T., Intra-tumor distribution of PEGylated liposome upon repeated injection: No possession by prior dose. J. Control. Release, 220, 406-413 (2015)
  2. Ando, H., Kobayashi, S., Abu Lila A.S., Essam Eldin N., Kato, C., Shimizu, T., Ukawa, M., Kawazoe, K., Ishida, T., Advanced therapeutic approach for the treatment of malignant pleural mesothelioma via the intrapleural administration of liposomal pemetrexed. J. Control. Release, 220, 29-36 (2015)
  3. Mima, Y., Hashimoto, Y., Shimizu, T., Kiwada, H., Ishida, T., Anti-PEG IgM is a major contributor to the accelerated blood clearance of polyethylene glycol-conjugated protein. Mol. Pharmaceutics, 12, 2429-2435 (2015)
  4. Shimizu, T., Mima, Y., Hashimoto, Y., Ukawa, M., Ando, H., Kiwada, H., Ishida, T., Anti-PEG IgM and complement system are required for the association of second doses of PEGylated liposomes with splenic marginal zone B cells. Immunobiol. 220, 1151-1160 (2015)
  5. Tarashima, N., Sumitomo, T., Ando, H., Furukawa, K., Ishida, T., Minakawa, N., Synthesis of DNA fragments containing 2’-deoxy-4’-selenonucleoside units using DNA polymerases: comparison of dNTPs with O, S and Se at the 4’-position in replication. Org. Biomol. Chem., 13, 6949-6952 (2015)
  6. Essam Eldin, N., Elnahas, H.M., Mahdy M.A., Ishida, T., Liposomal pemetrexed: Formulation, characterization and in vitro cytotoxicity studies for effective management of malignant pleural mesothelioma. Biol. Pharm.Bull., 38, 461-469 (2015)
  7. Hashimoto, Y., Shimizu, T., Abu Lila, A., Ishida, T., Kiwada, H., Relationship between the concentration of anti-polyethylene glycol (PEG) in immunoglobulin M (IgM) and the intensity of the accelerated blood clearance (ABC) phenomenon against PEGylated liposomes in mice. Biol. Pharm.Bull., 38, 417-424 (2015)
  8. Kawanishi, M., Hashimoto, Y., Shimizu, T., Sagawa, I., Ishida, T., Kiwada, H., Comprehensive analysis of PEGylated liposome-asscociated proteins relating to the accelerated blood clearance phenomenon by combination with shotgun analysis and conventional methods. Biotech. Appl. Biochem. 62, 547-555 (2015)
  9. Ukawa, M., Ando, H., Shimizu, T., Ishida, T., Pharmaceutics of Nanoparticles, A book chapter in Nanomaterials in Pharmacology, Chapter 11, in press, Lu, Z.R. and Sakuma, S. (Ed.), Springer Science+Business Media, New York, USA, 219-238 (2015)
  10. 石田竜弘、安藤英紀、実践 製剤学～そしてその基盤となる物理薬剤学～（飯村菜穂子、萩原琢男 編） 第11章 ドラッグデリバリーシステム（DDS）、447-471 第1版(2015)
  11. 石田竜弘、PEGに対する免疫反応～PEG修飾製剤の安全性に関する研究～、製剤機械技術学会誌、24, 78-83 (2015)

研究费获得状况

  1. コスメトロジー研究振兴财団「研究助成金」（新规）
  2. 武田科学振兴财団「薬学系研究奨励継続助成」（新规）
  3. 武田科学振兴财団「薬学系研究奨励」（新规）
  4. 科学研究费补助金「基盘叠」（新规）
  5. 科学研究费补助金「若手研究叠」（新规）
  6. 科学研究费补助金「若手研究叠」（新规）
  7. 永井記念薬学国際交流財団「Research Grant」（新規）
  8. 大阪コミュニティ财団「研究助成金」（新规）
  9. 日本科学协会「笹川科学研究助成金」（新规）
  10. 科学研究费补助金「挑戦的萌芽研究」（継続）
  11. 科学研究费补助金「研究活动スタート支援」（継続）

2014年度

  1. Suzuki, T., Ichihara, M., Hyodo, K., Yamamoto, E., Ishida, T., Kiwada, H., Kikuchi, H., Ishihara, H., Influence of dose and animal species on accelerated blood clearance of PEGylated liposomal doxorubicin. Int. J. Pharm. 476, 205-212 (2014)
  2. Saito, Y., Hashimoto, Y., Arai, M., Tarashima, N., Miyazawa, T., Miki, K., Takahashi, M., Furukawa, K., Yamazaki, N., Matsuda, A., Ishida, T., Minakawa, N., Chemistry, properties, and in vitro and in vivo applications of 2’-O-methoxyethyl-4’-thioRNA, a novel hybrid type of chemically-modified RNA. ChemBioChem, 15, 2535-2540 (2014)
  3. Hashimoto, Y., Abu Lila A., Shimizu, T., Ishida, T., Kiwada, H. B cell-intrinsic toll-like receptor 7 is responsible for the enhanced anti-PEG IgM production following injection of siRNA-containing PEGylated lipoplex in mice. J. Control. Release, 184, 1-8 (2014)
  4. Hashimoto, Y., Shimizu, T., Mima, Y., Abu Lila A., Ishida, T., Kiwada, H., Generation, characterization and in vivo biological activity of two distinct monoclonal anti-PEG IgMs. Toxicol. Appl. Pharmacol., 277, 30-38 (2014)
  5. Hashimoto, Y., Uehara, Y., Abu Lila A., Ishida, T., Kiwada, H., Activation of TLR9 by incorporated pDNA within PEG-coated lipoplex enhances anti-PEG IgM production. Gene Ther. 21, 593-598 (2014)
  6. Nakashima, T., Sako, N., Matsuda, T., Uematsu, N., Sakurai, K., Ishida, T., Novel Submicronized Rebamipide Liquid with Moderate Viscosity: Significant Effects on Oral Mucositis in Animal Models. Biol. Pharm. Bull, 37, 671-678 (2014)
  7. Nakamura, H., Doi, Y., Abu Lila, A.S., Nagao, A., Ishida, T., Kiwada, H., Sequential treatment of oxaliplatin-containing PEGylated liposome together with S-1 improves intratumor distribution of subsequent doses of oxaliplatin-containing PEGylated liposome. Eur. J. Pharm. Biopharm., 87, 142-151 (2014)
  8. Abu Lila, A.S., Uehara, Y., Ishida, T., Kiwada, H., Application of polyglycerol-coating to pDNA lipoplex for the evasion of the accelerated blood clearance (ABC) phenomenon in nucleic acid delivery. J. Pharm. Sci., 103, 557-566 (2014)
  9. Abu Lila, A.S., Kiwada, H., Ishida, T., Selective delivery of oxaliplatin to tumor tissue by nanocarrier system enhances the overall therapeutic efficacy of the encapsulated oxaliplatin. Biol. Pharm. Bull., 37, 206-211 (2014)
  10. Abu Lila, A.S., Ishida, T., Allen, T.M., Liposomal nanomedicine, in Frontiers of Nanobiomedical Research, Torchilin, V. (Ed.), World Scientific, 1, 1-53 (2014)

研究费获得状况

  1. 四国5大学男女共同参画推进连络协议会「女性研究者活动支援」（新规）
  2. 科学研究费补助金「研究活动スタート支援」（新规）
  3. テルモ科学技术振兴财団「国际交流助成金」（新规）
  4. 科学研究费补助金「挑戦的萌芽研究」（新规）
  5. 科学研究费补助金「特别研究员奨励费」（継続）
  6. 科学研究费补助金「基盘叠」（継続）

2013年度

  1. Nakashima, T., Uematsu, N., Shibamori, M., Sakurai, K., Ishida, T., Kiwada, H., Establishment of an X-ray irradiation-induced glossitis model in rats: biphasic elevation of proinflammatory cytokines and chemokines. J. Pharmacol. Exp. Ther., 347, 660-668 (2013)
  2. Abu Lila, A.S., Ichihara, M., Shimizu, T., Ishida, T., Kiwada, H., Ex-Vivo/In-Vitro Anti-Polyethylene Glycol (PEG) IgM Production From Murine Splenic B Cells Stimulated by PEGylated Liposome. Biol. Pharm. Bull, 36, 1842-1848 (2013)
  3. Abu Lila, A.S., Nawata, K., Shimizu, T., Ishida, T., Kiwada, H., Use of polyglycerol (PG), instead of polyethylene glycol (PEG), prevents induction of the accelerated blood clearance phenomenon against long-circulating liposomes upon repeated administration. Int. J. Pharm., 456, 235-242 (2013)
  4. Alaaeldin, E., Abu Lila, A.S., Moriyoshi, N., Sarahan, H.A., Ishida, T., Khaled A. Khale, Kiwada, H., The co-delivery of oxaliplatin abrogates the immunogenic response to PEGylated siRNA-lipoplex. Pharm. Res., 30, 2344-2354 (2013)
  5. Ichikawa, K., Asai, T., Shimizu, K., Yonezawa, S., Urakami, T., Miyauchi, H., Kawashima, H., Ishida, T., Kiwada, H., Oku, N., Suppression of immune response by antigen-decorated liposomes encapsulating model agents: A novel strategy for the treatment of allergy. J. Control. Release, 167, 284-289 (2013)
  6. Shimizu, T., Ishida, T., Kiwada, H., Transport of PEGylated liposomes from the splenic marginal zone to the follicle in the induction phase of the accelerated blood clearance phenomenon. Immunobiol. 218, 725-732 (2013)
  7. Nagao, A., Abu Lila, A.S., Ishida, T., Kiwada, H., Abrogation of the accelerated blood clearance phenomenon by SOXL regimen: Promise for clinical application. Int. J. Pharm., 441, 395-401 (2013)
  8. Abu Lila, A.S., Kiwada, H., Ishida, T., The accelerated blood clearance (ABC) phenomenon: Clinical challenge and approaches to manage. J. Control. Release, 172, 38-47 (2013)
  9. Ishida, T., Kiwada, H., Alteration of tumor microenvironment for improved delivery and intratumor distribution of nanocarriers. Biol. Pharm. Bull., 36, 692-697 (2013)
  10. Ishida, T., Kiwada, H., Anti-polyethyleneglycol (PEG) antibody response to PEGylated substances. Biol. Pharm. Bull., 36, 889-891 (2013)
  11. 石田竜弘、際田弘志、腫瘍内微小環境の能動的制御に基づくsiRNAデリバリー技術の開発とがん治療への展開、薬学雑誌、133, 379-386 (2013)
  12. 石田竜弘、際田弘志、PEG修飾製剤による抗PEG抗体分泌誘導、ファルマシア：最前線、49, 503-507 (2013)
  13. 石田竜弘、際田弘志、非経口投与製剤の開発と応用 ～次世代型医薬品の新規投与形態の開拓を目指して～（山本昌 監修） 第14章 注射による薬物投与と新規注射剤の開発 2節 腫瘍内微小環境の能動的制御に基づくDDSの開発とがん治療への応用、190-197 (2013)

研究费获得状况

  1. 科学研究费补助金「特别研究员奨励费」（新规）
  2. 永井记念薬学国际交流财団「研究助成金」（新规）
  3. 日本科学协会「海外発表促进助成金」（新规）
  4. 中富健康科学振兴财団「研究助成金」（新规）
  5. 大阪コミュニティ财団「研究助成金」（新规）
  6. 科学研究费补助金「基盘叠」（継続）
  7. 科学研究费补助金「基盘叠」（継続）

2012年度

  1. Abu Lila, A.S., Essam Eldin, N., Ichihara, M., Ishida, T., Kiwada, H., Multiple administration of PEG-coated liposomal oxaliplatin enhances its therapeutic efficacy: a possible mechanism and the potential for clinical application. Int. J. Pharm., 438, 176-183 (2012)
  2. Suzuki, T., Ichihara, M., Hyodo, K., Yamamoto, E., Ishida, T., Kiwada, H., Ishihara, H., Kikuchi, H., Accelerated blood clearance of PEGylated liposomes containing doxorubicin upon repeated administration to dogs. Int. J. Pharm., 436, 636-643 (2012)
  3. Shimizu, T., Ichihara, M., Yoshioka, Y., Ishida, T., Nakagawa, S., Kiwada, H., Intravenous administration of PEGylated proteins and PEGylated adenovirus elicits an anti-PEG IgM response. Biol. Pharm. Bull., 35, 1336-1342 (2012)
  4. Abu Lila, A.S., Matsumoto, H., Doi, Y., Nakamura, H., Ishida, T., Kiwada, H., Tumor type dependent vascular permeability constitutes a potential impediment to the therapeutic efficacy of liposomal oxaliplatin. Eur. J. Pharm. Biopharm., 81, 524-531 (2012)
  5. Barichello, J.M., Kizuki, S., Tagami, T., Luiz Alberto Lira Soares, L.A.L., Ishida, T., Kikuchi, H., Kiwada, H., Agitation during lipoplex formation harmonizes the interaction of siRNA to cationic liposomes. Int. J. Pharm., 430, 359-365 (2012)
  6. Abu Lila, A.S., Okada, T., Doi, Y., Ichihara, M., Ishida, T., Kiwada, H., Combination therapy with metronomic S-1 dosing and oxaliplatin-containing PEG-coated cationic liposomes in a murine colorectal tumor model: Synergy or antagonism? Int. J. Pharm., 426, 263-270 (2012)
  7. Tagami, T., Abu Lila, A.S., Matsunaga, M., Moriyoshi, N., Nakamura, H., Nakamura, K., Suzuki, T., Doi, Y., Ishida, T., Kiwada, H., Improved intratumoral delivery of PEG-coated siRNA-lipoplexes by combination with metronomic S-1 dosing in a murine solid tumor model. Drug Deliv. Transl. Res., 2, 77-86 (2012)
  8. Tagami, T., Suzuki, T., Matsunaga, M., Nakamura, K., Moriyoshi, N., Ishida, T., Kiwada, H., Anti-angiogenic therapy via cationic liposome-mediated systemic siRNA delivery. Int. J. Pharm., 422, 280-289 (2012)
  9. Ichihara, M., Moriyoshi, N., Abu Lila, A.S., Ishida, T., Kiwada, H., Anti-PEG IgM production via a PEGylated nano-carrier system for nucleic acid delivery. in Nanotechnology for Nucleic acid Delivery, Methods in Molecular Biology Oupicky, D. and Ogris, M. (Ed.), Springer, 948, 35-47 (2012)

研究费获得状况

  1. 武田科学振兴财団「研究助成金」（新规）
  2. テルモ科学技术振兴财団「国际交流助成金」（新规）
  3. 金原一郎记念医学医疗振兴财団「研究交流助成金」（新规）
  4. 科学研究费补助金「基盘叠」（新规）
  5. 高桥产业経済研究财団「研究助成金」（新规）
  6. 科学技术振兴财団?研究成果最适展开支援プログラム(础-厂罢贰笔)探索タイプ（継続）
  7. 科学研究费补助金「挑戦的萌芽研究」（継続）
  8. 科学研究费补助金「基盘叠」（継続）
  9. 科学研究费补助金「外国人特别研究员奨励费」（継続）
  10. 科学研究费补助金「若手研究叠」（継続）
  11. 平成22-24年度 徳岛大学パイロット事業支援プログラム(研究支援事業)「学長裁量経費」（継続）

2011年度

  1. Nakamura, K., Abu Lila A., Matsunaga, M., Doi, Y., Ishida, T., Kiwada H., A double-modulation strategy in cancer treatment with a chemotherapeutic agent and siRNA. Mol. Ther., 19, 2040-2047 (2011)
  2. Tagami, T., Suzuki, T., Hirose, K., Barichello, J.M., Yamazaki, N., Asai, T., Oku, N., Ishida, T., Kiwada, H., Argonaute2 is a potential target for siRNA-based cancer therapy for HT1080 human fibrosarcoma. Drug Deliv. and Transl. Res., 1, 277-288 (2011)
  3. Ichihara, M., Shimizu, T., Imoto, A., Hashiguchi, Y., Uehara, Y., Ishida, T., Kiwada, H., Anti-PEG IgM response against PEGylated liposomes in mice and rats. Pharmaceutics, 3, 1-11 (2011)
  4. Saito, A., Shimizu, H., Doi, Y., Ishida, T., Fujimura, M., Inoue, T., Kiwada, H., Tominaga, T., Immunoliposomal drug delivery system targeting lectin-like oxidized low density lipoprotein receptor 1 for carotid plaque lesion in rats. J. Neurosurgery. 115, 720-727 (2011)
  5. Barichello, J.M., Kizuki, S., Tagami, T., Asai, T., Ishida, T., Kikuchi, K., Oku, N., Kiwada, H., Agitation during lipoplex formation improves the gene knockdown effect of siRNA. Int. J. Pharm., 410, 153-160 (2011)
  6. Tagami, T., Uehara, Y., Moriyoshi, N., Ishida T., Kiwada, H., Anti-PEG IgM production by siRNA encapsulated in a PEGylated lipid nanocarrier is dependent on the sequence of the siRNA. J. Control. Release, 151, 149-154 (2011)
  7. Abu Lila A.S., Ishida, T., Kiwada, H., Cationic liposomes and tumour vasculature targeting: a therapeutic approach that has potential for solid tumours. A book chapter in Lipid Nanocarriers in Cancer Diagnosis and Therapy, Chapter 6, 137-168 (2011) Souto, E.B. (Ed.), i-Smithers - Creative Publishing Solutions
  8. 石田竜弘、際田弘志、PEG修飾リポソーム製剤繰り返し投与による血中滞留性低下、C&I Commun., 36, 19-21 (2011)
  9. 石田竜弘、リポソームDDSの開発研究～トランスレーショナルリサーチの実現を目指して～、薬剤学、71, 315-320 (2011)

研究费获得状况

  1. 科学技术振兴财団?研究成果最适展开支援プログラム（础-厂罢贰笔）探索タイプ（新规）
  2. 研究助成金「岛原科学振兴会」（新规）
  3. 科学研究费补助金「若手研究叠」（新规）
  4. 永井記念薬学国際交流財団「Research grant」（新規）
  5. 科学研究费补助金「若手研究础」（継続）
  6. 厚生労働省科学研究费「医疗机器开発推进研究事业（若手）」（継続）
  7. 平成22年度徳岛大学パイロット事業支援プログラム（研究支援事業）「学長裁量経費」（継続）
  8. 科学研究费补助金「基盘叠」（新规）
  9. 高桥产业経済研究财団「研究助成金」（新规）
  10. 科学研究费补助金?日本学术振兴会「特别研究员奨励费」（新规）

2010年度

  1. Ishihara, T., Maeda, T., Sakamoto, H., Takasaki, N., Shigyo, M., Ishida, T., Kiwada, H., Mizushima, Y., Mizushima, T., Evasion of the accelerated blood clearance phenomenon by coating of nanoparticles with various hydrophilic polymers. Biomacromolecules, 11, 2700-2706 (2010)
  2. Doi, Y., Okada, T., Matsumoto, H., Ichihara, M., Ishida, T., Kiwada, H., Combination therapy of metronomic S-1 dosing with oxaliplatin-containing PEG-coated liposome improves antitumor activity in a murine colorectal tumor model. Cancer Sci., 101, 2470-2475 (2010)
  3. Eto, Y., Yoshioka, Y., Ishida, T., Yao X., Morishige, T., Narimatsu, S., Mizuguchi, H., Mukai, Y., Okada, N., Kiwada, H., Nakagawa, S., Optimized PEGylated adenovirus vector reduces the anti-vector humoral immune response against adenovirus and induces a therapeutic effect against metastatic lung cancer. Biol. Pharm. Bull., 33, 1540-1544 (2010)
  4. Koide, H., Asai, T., Hatanaka, K., Akai, S., Ishii, T., Kenjo, E., Ishida, T., Kiwada, H., Tsukada, H., Oku, N., T cell-independent B cell response is responsible for ABC phenomenon induced by repeated injection of PEGylated liposomes. Int. J. Pharm., 392, 218-223 (2010)
  5. Yamazaki, H., Miyake, M., Kamada, N., Nishibayashi, T., Mukai, T., Odomi, M., Ishida, T., Kiwada, H., Co-administration of tacrolimus suppre sses pharmacokinetic modulation of multiple subcutaneously administrated human interferon-alpha in beagle dogs. Drug Metab. Pharmacokinet. 25, 149-154 (2010)
  6. Tagami, T., Nakamura, K., Shimizu, T., Yamazaki, N., Ishida, T., Kiwada, H., CpG motifs in pDNA-sequences increase anti-PEG IgM production induced by PEG-coated pDNA-lipoplexes. J. Control. Release, 142, 160-166 (2010)
  7. Abu Lila, A., Doi, Y., Nakamura, K., Ishida, T., Kiwada, H., Sequential administration with oxaliplatin-containing PEG-coated cationic liposomes promotes a significant delivery of subsequent dose into murine solid tumor. J. Control. Release, 142, 167-173 (2010)
  8. Abu Lila, A., Ishida, T., Kiwada, H., Targeting anticancer drugs to tumor vasculature using cationic liposomes. Pharm. Res., 27, 1171-1183 (2010)
  9. Doi, Y., Ishida, T., Kiwada, H., Breaking the barriers to tumor-targeting via nanocarrier-based drug delivery to the tumor microenvironment. A book chapter in Cancer Targeted Therapy, A book chapter in Neuro-Oncology and Cancer Targeted Therapy, Chapter 5, 141-160 (2010) Gutierrez, L.M. (Ed.), Nova Science Publishers
  10. Barichello, J. M., Ishida, T., Kiwada, H., Complexation of siRNA and pDNA with cationic liposomes: The important aspects in lipoplex preparation. A chapter, Liposomes, Methods Mol. Biol., 605, 461-472 (2010)
  11. 山崎浩之、三宅正晃、西林徹、向井正志、小富正昭、石田竜弘、際田弘志、タクロリムス共投与による蛋白質製剤頻回皮下投与時の特異抗体産生の抑制、薬剤学、70, 162 (2010)
  12. 石田竜弘、生体内動態検討を基盤としたリポソームDDSの開発～第2回日本DDS学会奨励賞（臨床）受賞によせて～、Drug Deliv. Sys., 25, 511-516 (2010)

研究费获得状况

  1. 平成22年度徳岛大学パイロット事業支援プログラム（研究支援事業）「学長裁量経費」
  2. 金原一郎记念医学医疗振兴财団「基础医学医疗研究助成金」
  3. 内藤记念科学振兴财団「内藤记念若手研究者海外派遣助成金」
  4. 科学研究费补助金「若手研究础」
  5. 厚生労働省科学研究费「医疗机器开発推进研究事业（若手）」
  6. 科学研究费补助金「基盘叠」
  7. テルモ科学技术振兴财団「国际交流助成金」

2009年度

  1. Ishihara, T., Takeda, M., Sakamoto, H., Kimoto, A., Kobayashi, C., Takasaki, N., Yuki, K., Tanaka, K., Takenaga, M., Igarashi, R., Maeda, T., Yamakawa, N., Okamoto, Y., Otsuka, M., Ishida, T., Kiwada, H., Mizushima, Y. and Mizushima, T., Accelerated blood clearance phenomenon upon repeated injection of PEG-modified PLA-nanoparticles. Pharm. Res., 26, 2270-2279 (2009)
  2. Yamazaki, H., Miyake, M., Nishibayashi, T., Mukai, T., Odomi, M., Ishida, T., Kiwada, H. Effect of co-administration of tacrolimus on the pharmacokinetics of multiple subcutaneous administered interferon-alpha in rats. Pharm. Res., 26, 1832-1837 (2009)
  3. Tagami, T., Nakamura, K., Shimizu, T., Ishida, T., Kiwada, H., Effect of siRNA in PEG-coated siRNA-lipoplex on the anti-PEG IgM production . J. Control. Release, 137, 234-240 (2009)
  4. Abu Lila, A., Kizuki, S., Doi, Y., Suzuki, T., Ishida, T., Kiwada, H., Oxaliplatin encapsulated in PEG-coated cationic liposomes induces significant tumor growth suppression via a dual-targeting approach in a murine solid tumor model. J. Control. Release, 137, 8-14 (2009)
  5. Isakari, Y., Sogo, S., Ishida, T., Kawakami, T., Ono, T., Taki, T., Kiwada, H., Gene expression analysis during platelet-like particle production in phorbol myristate acetate-treated MEG-01cells. Biol. Pharm. Bull. 32, 354-358 (2009)
  6. Ishida, T., Shiraga, E., Kiwada, H., Synergistic antitumor activity of metronomic dosing of cyclophosphamide in combination with doxorubicin-containing PEGylated liposomes in a murine solid tumor model. J. Control. Release, 134, 194-200 (2009)
  7. Abu-Lila, A, Suzuki, T., Doi, Y., Ishida, T., Kiwada, H., Oxaliplatin targeting to angiogenic vessels by PEGylated cationic liposomes suppresses the angiogenesis in a dorsal air sac mouse model. J. Control. Release, 134, 18-25 (2009)
  8. Abu Lila, A., Ishida, T., Kiwada, H., Recent advances in tumor vasculature targeting using liposomal drug delivery systems. Expert Opin. Drug Deliv., 6, 1297-309 (2009)
  9. Ishida, T., Kiwada, H., Synergistic antitumor activity of metronomic dosing chemotherapy in combination with liposomal anticancer drug. A book chapter in Anticancer Drugs: Design, Delivery and Pharmacology, Spencer, P. and Holt, W., Ed. Nova Science Publishers (2009)
  10. Ishida, T., Kiwada, H., Unexpected reactions by in vivo application of PEGylated liposomes. “Safety of Nanoparticles: From Manufacturing to Clinical Applications (A volume in the Nanostructure Science and Technology series)" T.J. Webster (Ed.), Chapter 6, p111-130, Springer Science + Business Media, New York, USA (2009)
  11. 小出裕之、浅井知浩、畑中剣太朗、清水広介、横山昌幸、石田竜弘、際田弘志、奥直人、PEG化キャリア頻回投与によるaccelerated blood clearance現象の機構解明、薬学雑誌, 129, 1445-1451 (2009)
  12. 石田竜弘、田上辰秋、際田弘志、siRNAを利用したArgonaute2遺伝子knockdownによるがん治療法の開発、和光純薬時報、Vol.77, No.2, 8-11 (2009)

研究费获得状况

  1. 科学技術振興機構 平成21年度「シーズ発掘試験A（発掘型）」
  2. 科学研究费补助金「若手研究础」
  3. 厚生労働省科学研究费「医疗机器开発推进研究事业（若手）」
  4. 科学研究费补助金「基盘叠」
  5. 科学研究费补助金「がん特定研究」
  6. がん研究に係わる特定领域研究?国际交流委员会「研究者海外派遣事业」
  7. 日本学术振兴会「国际学会等派遣事业」
  8. 平成21年度教育研究等支援事业「学长裁量経费」

2008年度

  1. Tagami, T., Hirose, K., Barichello, J.B., Ishida, T., Kiwada, H., Global gene expression profiling in cultured cells is strongly influenced by treatment with siRNA-cationic liposome complexes. Pharm. Res., 25, 2497-2504 (2008)
  2. Koide, H., Asai, T., Hatanaka, K., Urakami, T., Ishii, T., Kenjo, E., Nishihara, M., Yokoyama, M., Ishida, T., Kiwada, H., Oku, N., Particle size-dependent triggering of accelerated blood clearance phenomenon. Int. J. Pharm., 362, 197-200 (2008)
  3. Asai, T., Suzuki, Y., Matsushita, S., Yonezawa, S., Yokota, J., Katanasaka, Y., Ishida, T., Dewa, T., Kiwada, H., Nango, N., Oku, N., Disappearance of the angiogenic potential of endothelial cells caused by Argonaute2 knockdown. Biochem. Biophys. Res. Commun., 368, 243-248 (2008)
  4. Barichello, J.M., Yamakawa, N., Kisyuku, M., Handa, H., Shibata, T., Ishida, T., Kiwada, H., Combined effect of liposomalization and addition of glycerol on the transdermal delivery of isosorbide 5-nitrate in rat skin. Int. J. Pharm., 357, 199-205 (2008)
  5. Matsumura-Takeda, K., Ishida, T., Sogo, S., Isakari, Y., Taki, T., Sogo, T., Kiwada, H., Lactoferrin inhibits platelet production from human megakaryocytes in vitro. Biol. Pharm. Bull., 31, 569-573 (2008)
  6. Ishida, T., Kashima, S., Kiwada, H., The contribution of phagocytic activity of liver macrophages to the accelerated blood clearance (ABC) phenomenon of PEGylated liposomes in rats. J. Control. Release, 126, 162-165 (2008)
  7. Shiraga, E., Barichello, J.M., Ishida, T., Kiwada, H., A metronomic schedule of cyclophosphamide combined with PEGylated liposomal doxorubicin has a highly antitumor effect in an experimental pulmonary metastatic mouse model. Int. J. Pharm., 353, 65-73 (2008)
  8. Ishida, T., Kiwada, H., Accelerated blood clearance (ABC) phenomenon upon repeated injection. J. Control. Release, 354, 56-62 (2008)
  9. 石田竜弘、際田弘志、ポリエチレングリコール修飾リポソーム投与時に生ずるaccelerated blood clearance (ABC)現象、薬学雑誌、128, 233-243 (2008)
  10. 石田竜弘、腫瘍血管の構造変化がナノ粒子抗がん剤の効果を変化させる、ファルマシア、44, 168-169 (2008)

研究费获得状况

  1. 科学研究费补助金「基盘叠」
  2. 科学研究费补助金「がん特定研究」
  3. 科学研究费补助金「若手叠」
  4. 持田记念医学薬学振兴财団「研究助成金」
  5. 大和証券ヘルス财団「调査研究助成金」
  6. テルモ科学技术振兴财団「国际交流助成金」

2007年度

  1. Ishida, T., Wang X.Y., Shimizu, T., Nawata, K., Kiwada, H., PEGylated liposomes elicit an anti-PEG IgM response in a T-cells independent manner. J. Control. Release, 122, 349-355 (2007)
  2. Hatakeyama, H., Akita, H., Ishida, E., Hashimoto, K., Kobayashi, H., Aoki, T., Yasuda, J., Obata, K., Kikuchi, K., Ishida, T., Kiwada, H., Harashima, H., Tumor targeting of doxorubicin by anti MT1-MMP antibody-modified PEG liposomes. Int. J. Pharm., 342, 194-200 (2007)
  3. Wang, X.Y., Ishida, T., Kiwada, H., Anti-PEG IgM elicited by injection of liposomes is involved in the enhanced blood clearance of a subsequent dose of PEGylated liposomes. J. Control. Release, 119, 236-244 (2007)
  4. Isakari, Y., Harada, Y., Ishikawa, D., Matsumura-Takeda, K., Sogo, S., Ishida, T., Taki, T., Kiwada, H., Efficient gene expression in Megakaryocytic cell line using Nucleofection. Int. J. Pharm., 338, 157-164 (2007)
  5. Atobe, K., Ishida, T., Ishida, E., Hashimoto, K., Kobayashi, H., Yasuda, J., Aoki, T., Obata, K, Kikuchi, H., Akita, H., Asai, T, Harashima, H., Oku, N., Kiwada, H., In vitro efficacy of a sterically stabilized immunoliposomes targeted to membrane type 1 matrix metalloproteinase (MT1-MMP). Biol. Pharm. Bull., 30, 972-978 (2007)
  6. Nguyen, L.T., Atobe, K., Barichello, J.M., Ishida, T., Kiwada, H., Complex formation with plasmid DNA increases the cytotoxicity of cationic liposomes. Biol. Pharm. Bull., 30, 751-757 (2007)
  7. Tagami, T., Barichello, J.M., Kikuchi, H., Ishida, T., Kiwada, H., The gene-silencing effect of siRNA in cationic lipoplexes is enhanced by incorporating pDNA in the complex. Int. J. Pharm., 333, 62-69 (2007)
  8. Kobayashi, T., Ishida, T., Okada, Y., Ise, S., Harashima, H., Kiwada, H., Effect of Transferrin receptor-targeted liposomal doxorubicin in P-glycoprotein-mediated drug resistant tumor cells. Int. J. Pharm., 329, 94-102 (2007)
  9. 石田竜弘、際田弘志、ポリマー修飾ナノ微粒子投与による免疫活性化に関する研究、表面、45, 357-371 (2007)
  10. 石田竜弘、際田弘志、リポソームと細胞の相互作用（DDSへの応用）、膜、32, 18-24 (2007)
  11. 石田竜弘、デリバリーによる新たな創薬、薬事日報、10368号、P8, 2007年4月25日版

研究费获得状况

  1. 知的クラスター创成事业
  2. 厚生労働省科学研究费补助金
  3. 科学研究费补助金「がん特定研究」
  4. 科学研究费补助金「若手叠」
  5. テルモ科学技术振兴财団「国际交流助成金」
  6. 山阳放送学术文化财団

2006年度

  1. Ishida, T., Atobe, K., Wang, X., Kiwada, H., Accelerated blood clearance of PEGylated liposomes upon repeated injections: Effect of doxorubicin-encapsulation and high-dose first injection. J. Control. Release, 115, 251-258 (2006)
  2. Ishida, T., Ichihara, M., Wang, X., Kiwada, H., Spleen plays an important role in the induction of accelerated blood clearance of PEGylated liposomes. J. Control. Release, 115, 243-250 (2006)
  3. Barichello, J.M., Handa, H., Kisyuku, M., Shibata, T., Ishida, T., Kiwada, H., Inducing effect of liposomalization on the transdermal delivery of hydrocortisone: creation of a drug supersaturated state. J. Control. Release, 115, 94-102 (2006)
  4. Ishida, T., Ichihara, M., Wang X.W., Yamamoto, K., Kimura, J., Majima, E., Kiwada, H., Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes. J. Control. Release, 112, 15-25 (2006)
  5. Dang, F., Li, W., Zhang, L., Jabasini, M., Ishida, T., Kiwada, H., Kaji, N., Tokeshi, M., Baba, Y., Electrophoretic behavior of plasmid DNA in the presence of various intercalating dyes. J. Chromatography A, 1118, 218-225 (2006)
  6. Ishida, T., Li, W., Liu, Z., Kiwada, H., Stimulatory effect of polyethylene glycol (PEG) on gene expression in mouse liver following hydrodynamics-based transfection. J. Gene Med., 8, 324-334 (2006)
  7. Ishida, T., Okada, O., Kobayashi, T., Kiwada, H., Development of pH-sensitive liposomes that efficiently retain encapsulated doxorubicin (DXR) in blood. Int. J. Pharm., 309, 94-100 (2006)
  8. Ishida, T., Takanashi, Y., Kiwada, H., Safe and efficient drug delivery system with liposomes for intrathecal application of an antivasospastic drug, fasudil. Biol. Pharm. Bull., 29, 397-402 (2006)
  9. 石田竜弘、際田弘志、がん治療を目指した機能性リポソームの開発研究、化学工業、57, 39-43 (2006)

研究费获得状况

  1. 知的クラスター创成事业
  2. 厚生労働省科学研究费补助金
  3. 科学研究费补助金「がん特定研究」
  4. 包括的研究连携（大鹏薬品工业）
  5. 原口记念癌研究助成基金
  6. 花王芸术?科学财団
  7. 住友财団

2005年度

  1. Wang, XY, Ishida, T., Ichihara, M., Kiwada, H., Influence of the physicochemical properties of liposomes on the accelerated blood clearance phenomenon in rats. J. Control.Release, 104, 91-102 (2005)
  2. Li, W., Ishida, T., Okada, Y., Oku, N., Kiwada, H., Increased gene expression by cationic liposomes (TFL-3) in lung metastases following intravenous injection. Biol. Pharm. Bull., 28, 701-706 (2005)
  3. Tsuchiya, K., Kanematsu, Y., Yoshizumi, M., Ohnishi, H., Kirima, K., Izawa, Y., Shikishima, M., Ishida, T., Kondo, S., Kagami, S., Takiguchi, Y., Tamaki, T., Nitrite is an alternative source of NO in vivo. Am. J. Physiol. Heart Circ. Physiol. 288: H2163-2170 (2005)
  4. Ishida, T., Harada, M., Wang, X.Y., Ichihara, M., Irimura, K., Kiwada, H., Accelerated blood clearance of PEGylated liposomes following preceding liposome injection: effects of lipid dose and PEG surface-density and chain length of the first-dose liposomes. J. Control. Release, 105, 305-317 (2005)
  5. Nguyen, L.T., Ishida, T., Kiwada, H., Gene expression in primary cultured mouse hepatocytes with a cationic liposomal vector, TFL-3: Comparison with rat hepatocytes. Biol. Pharm. Bull., 28, 1472-1475 (2005)
  6. 石田竜弘、冨永洋子、綾野早笑、高梨吉裕、塚田秀夫、奥直人、際田弘志、髄液内投与可能なDDSの開発とその脳脊髄腔内動態に関する研究、臨床薬理の進歩、26, 171-178 (2005)
  7. 石田竜弘、際田弘志、リポソーム応用の新展開 ～人工細胞の開発に向けて～（秋吉一成、辻井薫 編） 第10章 医学薬学でのリポソーム応用 3節 長期血中滞留性リポソーム (2005)
  8. 石田竜弘、際田弘志、リポソーム応用の新展開 ～人工細胞の開発に向けて～（秋吉一成、辻井薫 編） 第10章 医学薬学でのリポソーム応用 1節 リポソームと細胞の相互作用 (2005)
  9. 石田竜弘、リポソームDDSの開発研究、薬剤学、65、28-33 (2005)

研究费获得状况

  1. 厚生労働省科学研究费补助金
  2. 包括的研究连携（大鹏薬品工业）
  3. 科学研究费补助金「若手叠」
  4. 黒住医学研究振兴财団

2004年度

  1. Li, W., Ishida, T., Tachibana R., Almofti, M.R., Wang X., Cell type-specific gene expression, mediated by TFL-3, a cationic liposomal vector, is controlled by a post-transcription process of delivered plasmid DNA. Int. J. Pharm., 276, 67-74 (2004)
  2. Ishida, T., Ichikawa, T., Ichihara, M., Sadzuka, Y., Kiwada, H., Effect of the physicochemical properties of initially injected liposomes on the clearance of subsequently injected PEGylated liposomes in mice. J. Control. Release, 95, 403-412 (2004)
  3. Tachibana, R., Ide, N., Shinohara, Y., Harashima, H., Hunt, C.A., Kiwada, H., An assessment of relative transcriptional availability from nonviral vectors. Int. J. Pharm., 270, 315-321 (2004)
  4. 石田竜弘、際田弘志、ポリエチレングリコール表面修飾リポソームの繰り返し投与時に発現するaccelerated blood clearance (ABC)現象、Drug Deliv. Sys., 19, 495-510 (2004)
  5. 石田竜弘、高梨吉裕、際田弘志、能脊髄腔内直接投与可能なDDSの開発とその脳保護効果、薬事、1333-1338 (2004)
  6. 石田竜弘、脳脊髄腔内直接投与可能なDDSの開発とその脳保護効果の検討、薬学雑誌、124, 541-547 (2004)

研究费获得状况

  1. 科学研究费补助金「若手叠」
  2. 原口记念癌研究助成基金
  3. 薬理研究会
  4. 佐川がん研究助成振兴财団

2003年度

  1. Nguyen, N.L., Ishida, T., Ukitsu, S., Li, W.H., Tachibana, R., Kiwada, H., Culture-time dependent gene expression in isolated primary cultured rat hepatocytes by transfection with a cationic liposomal vector, TFL-3. Biol. Pharm. Bull., 26, 880-885 (2003)
  2. Ishida, T., Masuda, K., Ichikawa, T., Ichihara, M., Irimura, K., Kiwada, H., Accelerated clearance of a second injection of PEGylated liposomes in mice. Int. J. Pharm., 255, 167-174 (2003)
  3. Ishida, T., Maeda, R., Ichihara, M., Irimura, K., Kiwada, H., Accelerated clearance of PEGylated liposomes in rats after repeated injections. J. Control. Release, 88, 35-42 (2003)
  4. Tachibana, R., Futaki, S., Harashima, H., Kiwada, H., pH-sensitive liposomes in nuclear targeting of macromolecules. Methods in Enzymol., 372, 349-361 (2003)
  5. Almofti, M.R., Harashima, H., Shinohara, Y., Almofti, A., Li, W.H., Kiwada, H., Lipoplex size determines lipofection efficiency with or without serum. Mol. Mem. Biol., 20, 35-43 (2003)
  6. Almofti, M.R., Harashima, H., Shinohara, Y., Almofti, A., Li, W.H., Baba, Y., Kiwada, H., Cationic liposome-mediated gene delivery: Biophysical study and mechanism of internalization. Arch. Biochem. Biophys., 410, 246-253 (2003)
  7. 石田竜弘、際田弘志、DDS研究の現状、科学フォーラム、2003-12, 22-28 (2003)
  8. 石田竜弘、機能性リポソームの開発とその癌治療への応用、薬事、45, 1125-1132 (2003)
  9. 石田竜弘、癌と人、30, 28-29 (2003)

研究费获得状况

  1. 科学研究费补助金「若手叠」
  2. 日本科学协会
  3. 薬学研究奨励财団
  4. 上原记念生命科学财団
  5. 临床薬理研究财団
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