本分野では、内分泌代谢疾患や代谢性骨疾患ならびに肾疾患における病态解明や新规治疗标的となる分子に焦点を当てて研究を展开している。具体的には遗伝子改変マウスモデルの解析および临床研究を融合し、1)&苍产蝉辫;代谢性骨疾患における病态の解明と新规治疗法の开発、2)&苍产蝉辫;メタボリック症候群/糖尿病と骨粗鬆症の连関、3)&苍产蝉辫;骨脆弱性をきたすホルモンおよび颁补/笔代谢异常、4)肾疾患における病态の解明と新规治疗法の开発について検讨を进めている。
Our department focuses on the areas of endocrine disorders, metabolic bone diseases and nephropathy. Our research goal is elucidation of the molecular mechanisms of these disorders as well as development of molecular-targeted therapy against these diseases by using translational and clinical research methods. We have the following research project. 1) Analysis molecular mechanisms and development of newly therapeutic methods for metabolic bone diseases. 2) Elucidation of the pathological interplay between metabolic syndrome/diabetes mellitus and osteoporosis. 3) Clarification of the pathophysiology of bone fragility depends on dysfunction of endocrine system and/or abnormal calcium/phosphate metabolism. 4)Analysis molecular mechanisms and development of newly therapeutic methods for nephropathy.
