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The 91̽�� Seeds Collection

The 91̽�� Seeds Collection aims to promote new collaborations with industry and local governments by introducing overviews of research conducted at 91̽��, along with related academic publications and intellectual property. 
Each research seed also includes its potential applications and commercialization prospects, making it a useful resource for exploring themes for joint research and new business initiatives.

Life Sciences / Engineering / Food Science

Life Sciences

No.	Title/Subtitle	Researcher(s)	Classi?cation
L-01	An Innovative Immunization Technique for Efficient Induction of Antibodies Against Membrane Proteins  — Development of an Innovative Antibody Induction Platform Using Spleen-Targeted DDS Technology —		Basic Research
L-02	Toward Widespread Clinical and Societal Adoption of Ultra-High-Sensitivity MRI — Nuclear Spin Polarization Technology via Eutectic and Co-Crystal Methods —		Basic Research
L-03	A Platform Technology to Accelerate Biopharmaceutical Development —    Toward Integrated Development of Protein Therapeutics, Production Cell Lines, and Bioprocesses —		Basic Research
L-04	NMR-Based Technologies for Analyzing Biomolecule Dynamics — Investigating Protein Interactions, 3D Structures, and Dynamics in Solution at Atomic Resolution —		Basic Research
L-05	Application of PET Imaging to Theranostics — From Non-Invasive “Seeing” Cancer to Truly “Diagnosing” It —		Basic Research
L-06	Drug Repositioning for Chronic Pain — Efficacy of Tranilast in Trigeminal Neuropathic Pain —		Basic Research
L-07	Rapid Development Technology for Humanized Single-Domain Antibodies — A New Modality for Biosensor and Therapeutic Antibody Development —		Basic Research
L-08	Development of Novel Drug Discovery Technologies Based on the Epitranscriptome — Elucidation of New Homeostatic Mechanisms of Methylated RNA through Comprehensive Analyses and Exploration of Novel Drug Discovery Seeds —	Nazere Keyoumu	Basic Research
L-09	Lysoplasmalogen as a Biomarker for Skin Inflammation and Barrier Function — A Novel Bioactive Lysophospholipid Involved in Skin Homeostasis and Chronic Inflammatory Skin Diseases —		Basic Research
L-10	Development of a Novel Clear Index System for Direct Composite Restoration — Standardizing High-Quality Direct Composite Restoration to Advance Minimally Invasive Dentistry —		Demonstration Research
L-11	A Non-Contact, Non-Invasive Technology for Intradermal Delivery of Macromolecules — Widespread Skin Penetration of Pharmaceuticals and Cosmetic Ingredients Using an “Electric Bath” —		Basic Research
L-12	Lipid Nanoparticle Formulation Technology Exhibiting High Translocation and Accumulation in Pancreatic Islets and Exocrine Pancreatic Tissue — Development of a Delivery Platform for Pancreas-Targeted Therapeutics —		Basic Research
L-13	“Mimamoru-kun II”: Realizing System and Human Collaboration Between Dental Care, Medical Care, and Welfare/Care Services — An AI Engine Aimed at Behavioral Change Through Lifestyle Improvement Recommendations —		Basic Research
L-14	Development of a Dental Caries Prevention Tool Using Cross-Modal Perception — A Predictive Experience of Toothache Caused by Dental Caries —	Naoya Tanigaki	Basic Research
L-15	Regulation of Fibrocytes by Clock Gene Inhibitors and Their Application to Cancer Therapy — Toward the Development of Novel Treatments to Overcome Resistance to Immunotherapy —		Basic Research
L-16	Manufacturing Method of Zwitterionic Compounds with Superior Protein Adsorption Resistance — Water-Soluble Antithrombotic Materials with Covalent Binding Capability to Metal and Glass Substrates —		Basic Research
L-17	Development of a VR-Based Tailor-made Toothbrushing Training Tool — A Self-Check Gamified System for Achieving Better Oral Health —	Kotone Yamashita	Basic Research
L-18	Automated Image Analysis Technology for Quantifying the “Connectivity” of Liver Fibrosis Lesions �D Toward the Establishment of a Diagnostic Support System for Pathology �D		Basic Research

Machinery / Environment / Energy / Civil Engineering / Architecture

No.	Title/Subtitle	Researcher(s)	Classi?cation
E-01	Miniaturization and High-Power Output of Small Hydropower Generation Using a Contra-Rotating Rotor  — Effective Utilization of Energy Losses through a Pressure-Reducing Valve Equipped with an Inline Small Hydroturbine —		Demonstration Research
E-02	High-Precision Positioning Control Technology for Pneumatic Actuators — Achieving Both Contact Safety and Nanometer-Scale Precision in Collaborative Robot Applications —		Demonstration Research
E-03	Development of a High-Accuracy, High-Speed Tsunami Simulator (JAGURS) — For Probabilistic Evaluation of Tsunami Events Toward Optimal Disaster countermeasures—		Demonstration Research
E-04	Application of Multimodal Emotion Estimation Technology for Supporting the Diagnosis of Mental Disorders — Achieving Emotion Estimation with Interpretability and Causal Inference —		Demonstration Research
E-05	Large-Area Nondestructive Inspection Technology Using Infrared Active Thermography  — Nondestructive Inspection Contributing to the Maintenance of Large-Scale Structures —		Demonstration Research

Food / Agriculture, Forestry, and Fisheries

No.	Title/Subtitle	Researcher(s)	Classi?cation
B-01	Research on Extending Shelf Life and Reducing Food Loss Using a Library of Food Spoilage Bacteria  — We aim to achieve rapid, low-cost microbial identification and the construction of a highly reliable library of food spoilage bacteria —		Basic Research
B-02	Visualization of Food Components by High-Sensitivity Mass Spectrometry Imaging — Contributing to Food Safety and Quality Improvement through Mass Spectrometry Imaging —		Applied Research

Last updated date��October 15, 2026